Ouzounian Maral, Lee Douglas S, Gramolini Anthony O, Emili Andrew, Fukuoka Masahiro, Liu Peter P
Heart and Stroke/Richard Lewar Centre for Excellence, University of Toronto.
Can J Cardiol. 2007 Aug;23 Suppl A(Suppl A):28A-33A. doi: 10.1016/s0828-282x(07)71003-6.
Genomic and proteomic approaches to cardiovascular medicine promise to revolutionize our understanding of disease initiation and progression. This improved appreciation of pathophysiology may be translated into avenues of clinical utility. Gene-based presymptomatic prediction of illness, finer diagnostic subclassifications and improved risk assessment tools will permit earlier and more targeted intervention. Pharmacogenetics will guide our therapeutic decisions and monitor response to therapy. Personalized medicine will require the integration of clinical information, stable and dynamic genomics, and molecular phenotyping. Bioinformatics will be crucial in translating these data into useful applications, leading to improved diagnosis, prediction, prognostication and treatment. The present paper reviews the potential contributions of genomic and proteomic approaches in developing a more personalized approach to cardiovascular medicine.
心血管医学中的基因组学和蛋白质组学方法有望彻底改变我们对疾病发生和发展的理解。对病理生理学的这种更深入认识可能会转化为临床应用途径。基于基因的疾病症状前预测、更精细的诊断亚分类以及改进的风险评估工具将允许更早且更有针对性的干预。药物遗传学将指导我们的治疗决策并监测治疗反应。个性化医疗将需要整合临床信息、稳定和动态的基因组学以及分子表型分析。生物信息学对于将这些数据转化为有用的应用至关重要,从而改善诊断、预测、预后和治疗。本文综述了基因组学和蛋白质组学方法在发展更个性化的心血管医学方法方面的潜在贡献。