Amanullah Muneer, Hasan Asif, Roe Jo, Dunning Joel
Department of Cardiothoracic Surgery, Freeman Hospital, Freeman Road, Newcastle upon Tyne NE7 7DN, UK.
Interact Cardiovasc Thorac Surg. 2004 Sep;3(3):499-502. doi: 10.1016/j.icvts.2004.04.001.
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was whether prophylactic administration of steroids is of benefit to children undergoing cardiac surgery? Altogether 302 papers were found using the reported search, of which six represented the best evidence. The author, journal, date and country of publication, patient group studied, study type, relevant outcomes, results, and study weaknesses were tabulated. We conclude that steroids may reduce Troponin I release, CRP and reduce Interleukin-6. In addition, two studies, each in only 30 patients, found some evidence for improvements in clinical parameters such as ICU stay and fluid requirement. These findings need confirmation prior to any firm recommendations as to the clinical benefits of steroids.
一篇心脏外科的最佳证据主题文章是按照结构化方案撰写的。所探讨的问题是预防性使用类固醇对接受心脏手术的儿童是否有益？通过报告的检索共找到302篇论文，其中6篇代表了最佳证据。将作者、期刊、出版日期和国家、所研究的患者群体、研究类型、相关结果、研究结果以及研究的不足之处制成表格。我们得出结论，类固醇可能会减少肌钙蛋白I的释放、降低C反应蛋白并减少白细胞介素-6。此外，两项研究（每项研究仅30名患者）发现了一些证据，表明在诸如重症监护病房停留时间和液体需求量等临床参数方面有所改善。在就类固醇的临床益处给出任何确切建议之前，这些发现需要得到证实。
