Ercolani P, Giovagnoni A, Giuseppetti G, Baldassarre S, De Nigris E, Amici F
Istituto di Semeiologia, Diagnostica e Terapia Strumentale Università, Ancona.
Radiol Med. 1991 Oct;82(4):422-6.
MR imaging was employed for the identification and tissue characterization of nodular lesions in the breast. The study had poor outcome, but the clinical introduction of a paramagnetic contrast medium, Gd-DTPA, allowed better results to be obtained. This study was aimed at evaluating the possibilities of Gd-DTPA enhanced MRI in differentiating benign from malignant breast nodules and in staging cancer. Final diagnosis was made by means of either histology, in the patients who underwent surgery, or cytology. Sixty-one patients with nodules at mammography and US were examined with MRI. The results of US, mammography, and MRI were blindly evaluated and proved that combined mammography and US, together with Gd-DTPA enhanced MRI, correctly identified all nodular lesions. Moreover, enhanced MRI allowed benign lesions to be distinguished from malignant nodules. MRI with Gd-DTPA correctly assessed both T parameter and pectoral muscle infiltration. MRI cannot replace mammography, which is a quick and inexpensive examination, but it should be performed as an adjunct in the cases of questionable radiographic and US findings and to stage breast cancer.
磁共振成像(MR成像)用于乳腺结节性病变的识别和组织特征分析。该研究结果不佳,但顺磁性造影剂钆喷酸葡胺(Gd-DTPA)的临床应用使结果得到了改善。本研究旨在评估Gd-DTPA增强磁共振成像在鉴别乳腺良恶性结节以及癌症分期方面的可能性。最终诊断通过对接受手术患者的组织学检查或细胞学检查来确定。对61例在乳腺X线摄影和超声检查中发现有结节的患者进行了磁共振成像检查。对超声、乳腺X线摄影和磁共振成像的结果进行了盲法评估,结果表明乳腺X线摄影和超声检查与Gd-DTPA增强磁共振成像相结合能够正确识别所有结节性病变。此外,增强磁共振成像能够区分良性病变和恶性结节。使用Gd-DTPA的磁共振成像能够正确评估T参数和胸肌浸润情况。磁共振成像不能替代乳腺X线摄影,后者是一种快速且费用低廉的检查方法,但在乳腺X线摄影和超声检查结果存疑的情况下,磁共振成像应作为辅助检查手段用于乳腺癌的分期。