自噬的诱导不影响2型人鼻病毒的产生。
Induction of autophagy does not affect human rhinovirus type 2 production.
作者信息
Brabec-Zaruba Marianne, Berka Ursula, Blaas Dieter, Fuchs Renate
机构信息
Department of Pathophysiology, Medical University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria.
出版信息
J Virol. 2007 Oct;81(19):10815-7. doi: 10.1128/JVI.00143-07. Epub 2007 Aug 1.
Abstract
Induction of autophagy has been shown to be beneficial for the replication of poliovirus, a phenomenon that might also apply for other picornaviruses. We demonstrate that de novo synthesis of human rhinovirus type 2 (HRV2), an HRV of the minor receptor group, is unaffected by tamoxifen, rapamycin, and 3-methyladenine (3-MA), drugs either stimulating (tamoxifen and rapamycin) or inhibiting (3-MA) autophagic processes. Furthermore, LC3-positive vesicles (i.e., autophagosomes) are not induced upon infection. Therefore, multiplication of this particular picornavirus is not dependent on autophagy.
摘要
自噬的诱导已被证明对脊髓灰质炎病毒的复制有益，这一现象可能也适用于其他小核糖核酸病毒。我们证明，2型人鼻病毒（HRV2，小受体组的一种HRV）的从头合成不受他莫昔芬、雷帕霉素和3-甲基腺嘌呤（3-MA）的影响，这些药物要么刺激（他莫昔芬和雷帕霉素）要么抑制（3-MA）自噬过程。此外，感染后不会诱导产生LC3阳性囊泡（即自噬体）。因此，这种特定小核糖核酸病毒的增殖不依赖于自噬。
相似文献
1
Induction of autophagy does not affect human rhinovirus type 2 production.
J Virol. 2007 Oct;81(19):10815-7. doi: 10.1128/JVI.00143-07. Epub 2007 Aug 1.
2
Porcine reproductive and respiratory syndrome virus induces autophagy to promote virus replication.
Autophagy. 2012 Oct;8(10):1434-47. doi: 10.4161/auto.21159. Epub 2012 Jun 28.
3
Induction of Atypical Autophagy by Porcine Hemagglutinating Encephalomyelitis Virus Contributes to Viral Replication.
Front Cell Infect Microbiol. 2017 Feb 28;7:56. doi: 10.3389/fcimb.2017.00056. eCollection 2017.
4
3-Methyladenine induces cell death and its interaction with chemotherapeutic drugs is independent of autophagy.
Biochem Biophys Res Commun. 2013 Mar 1;432(1):5-9. doi: 10.1016/j.bbrc.2013.01.106. Epub 2013 Feb 5.
5
Autophagy Negatively Regulates Transmissible Gastroenteritis Virus Replication.
Sci Rep. 2016 Mar 31;6:23864. doi: 10.1038/srep23864.
6
Junín virus induces autophagy in human A549 cells.
PLoS One. 2019 Jun 19;14(6):e0218730. doi: 10.1371/journal.pone.0218730. eCollection 2019.
7
Porcine teschovirus 2 induces an incomplete autophagic response in PK-15 cells.
Arch Virol. 2018 Mar;163(3):623-632. doi: 10.1007/s00705-017-3652-2. Epub 2017 Nov 25.
8
The pancreatitis-induced vacuole membrane protein 1 triggers autophagy in mammalian cells.
J Biol Chem. 2007 Dec 21;282(51):37124-33. doi: 10.1074/jbc.M706956200. Epub 2007 Oct 16.
9
Autophagy activation is associated with neuroprotection in a rat model of focal cerebral ischemic preconditioning.
Autophagy. 2010 May;6(4):482-94. doi: 10.4161/auto.6.4.11737. Epub 2010 May 16.
10
Autophagy influences maternal mRNA degradation and apoptosis in porcine parthenotes developing in vitro.
J Reprod Dev. 2012;58(5):576-84. doi: 10.1262/jrd.2012-005. Epub 2012 Jul 2.
引用本文的文献
1
The relationship between autophagy and respiratory viruses.
Arch Microbiol. 2024 Mar 4;206(4):136. doi: 10.1007/s00203-024-03838-3.
2
Rhinovirus and Cell Death.
Viruses. 2021 Apr 7;13(4):629. doi: 10.3390/v13040629.
3
Stimulator of interferon genes (STING) is an essential proviral host factor for human rhinovirus species A and C.
Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27598-27607. doi: 10.1073/pnas.2014940117. Epub 2020 Oct 15.
4
Autophagy in Negative-Strand RNA Virus Infection.
Front Microbiol. 2018 Feb 13;9:206. doi: 10.3389/fmicb.2018.00206. eCollection 2018.
5
The Autophagic Machinery in Enterovirus Infection.
Viruses. 2016 Jan 27;8(2):32. doi: 10.3390/v8020032.
6
Aspartyl Protease-Mediated Cleavage of BAG6 Is Necessary for Autophagy and Fungal Resistance in Plants.
Plant Cell. 2016 Jan;28(1):233-47. doi: 10.1105/tpc.15.00626. Epub 2016 Jan 6.
7
Coxsackievirus A16 elicits incomplete autophagy involving the mTOR and ERK pathways.
PLoS One. 2015 Apr 8;10(4):e0122109. doi: 10.1371/journal.pone.0122109. eCollection 2015.
8
Phosphoinositide-3 kinase inhibition modulates responses to rhinovirus by mechanisms that are predominantly independent of autophagy.
PLoS One. 2014 Dec 26;9(12):e116055. doi: 10.1371/journal.pone.0116055. eCollection 2014.
9
Membranous replication factories induced by plus-strand RNA viruses.
Viruses. 2014 Jul 22;6(7):2826-57. doi: 10.3390/v6072826.
10
Visualization of DC-SIGN-mediated entry pathway of engineered lentiviral vectors in target cells.
PLoS One. 2013 Jun 28;8(6):e67400. doi: 10.1371/journal.pone.0067400. Print 2013.
本文引用的文献
1
Calpain is required for macroautophagy in mammalian cells.
J Cell Biol. 2006 Nov 20;175(4):595-605. doi: 10.1083/jcb.200601024. Epub 2006 Nov 13.
2
Quantitative monitoring of autophagic degradation.
Biochem Biophys Res Commun. 2006 Dec 8;351(1):71-7. doi: 10.1016/j.bbrc.2006.09.168. Epub 2006 Oct 12.
3
AMP-activated protein kinase and the regulation of autophagic proteolysis.
J Biol Chem. 2006 Nov 17;281(46):34870-9. doi: 10.1074/jbc.M605488200. Epub 2006 Sep 21.
4
Wortmannin delays transfer of human rhinovirus serotype 2 to late endocytic compartments.
Biochem Biophys Res Commun. 2006 Sep 22;348(2):741-9. doi: 10.1016/j.bbrc.2006.07.125. Epub 2006 Jul 31.
5
Aggresomes and autophagy generate sites for virus replication.
Science. 2006 May 12;312(5775):875-8. doi: 10.1126/science.1126766.
6
Lithium induces autophagy by inhibiting inositol monophosphatase.
J Cell Biol. 2005 Sep 26;170(7):1101-11. doi: 10.1083/jcb.200504035.
7
The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death.
J Cell Sci. 2005 Jul 15;118(Pt 14):3091-102. doi: 10.1242/jcs.02447. Epub 2005 Jun 28.
8
The minor receptor group of human rhinovirus (HRV) includes HRV23 and HRV25, but the presence of a lysine in the VP1 HI loop is not sufficient for receptor binding.
J Virol. 2005 Jun;79(12):7389-95. doi: 10.1128/JVI.79.12.7389-7395.2005.
9
Subversion of cellular autophagosomal machinery by RNA viruses.
PLoS Biol. 2005 May;3(5):e156. doi: 10.1371/journal.pbio.0030156. Epub 2005 Apr 26.
10
Opening of size-selective pores in endosomes during human rhinovirus serotype 2 in vivo uncoating monitored by single-organelle flow analysis.
J Virol. 2005 Jan;79(2):1008-16. doi: 10.1128/JVI.79.2.1008-1016.2005.
Zotero 插件