Department of Bacteriology and Virology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Arch Microbiol. 2024 Mar 4;206(4):136. doi: 10.1007/s00203-024-03838-3.
Respiratory viruses have caused severe global health problems and posed essential challenges to the medical community. In recent years, the role of autophagy as a critical process in cells in viral respiratory diseases has been noticed. One of the vital catabolic biological processes in the body is autophagy. Autophagy contributes to energy recovery by targeting and selectively directing foreign microorganisms, organelles, and senescent intracellular proteins to the lysosome for degradation and phagocytosis. Activation or suppression of autophagy is often initiated when foreign pathogenic organisms such as viruses infect cells. Because of its antiviral properties, several viruses may escape or resist this process by encoding viral proteins. Viruses can also use autophagy to enhance their replication or prolong the persistence of latent infections. Here, we provide an overview of autophagy and respiratory viruses such as coronavirus, rhinovirus, parainfluenza, influenza, adenovirus, and respiratory syncytial virus, and examine the interactions between them and the role of autophagy in the virus-host interaction process and the resulting virus replication strategy.
呼吸道病毒引发了严重的全球健康问题，并对医学界构成了重大挑战。近年来，自噬作为细胞内病毒呼吸道疾病的关键过程的作用引起了人们的关注。自噬是体内重要的分解代谢生物过程之一。自噬通过靶向和选择性地将外来微生物、细胞器和衰老的细胞内蛋白引导到溶酶体进行降解和吞噬，有助于能量回收。当外来病原体如病毒感染细胞时，通常会启动自噬的激活或抑制。由于其抗病毒特性，一些病毒可能通过编码病毒蛋白来逃避或抵抗这一过程。病毒还可以利用自噬来增强其复制或延长潜伏感染的持续时间。在这里，我们概述了自噬以及冠状病毒、鼻病毒、副流感病毒、流感病毒、腺病毒和呼吸道合胞病毒等呼吸道病毒，并研究了它们之间的相互作用以及自噬在病毒-宿主相互作用过程中的作用以及由此产生的病毒复制策略。
