Uzan S, Uzan M, Beaufils M
Maternité Guy-Le-Lorier, Hôpital Tenon, Paris.
Rev Fr Gynecol Obstet. 1991 Feb 25;86(2 Pt 2):158-63.
The origin of pre-eclampsia lies in uteroplacental ischemia due to an anomaly of the "vascular insertion" of the placenta. Although the cause of this anomaly remains unknown, it would appear to include both a genetic and an immunological origin possibly favourised by special underlying conditions and certain obstetric circumstances. Prostaglandin imbalance (in particular prostacyclins and Thromboxane A2) appears to be one of the chief factors governing these anomalies. One of the consequences of these mechanisms is the onset of hypertension but other disturbances are essential features. In particular, disseminated intravascular coagulation may occur leading to the release of numerous microthrombi which cause placental (leading to chronic fetal distress), renal, hepatic and cerebral lesions.
子痫前期的起源在于胎盘“血管植入”异常导致的子宫胎盘缺血。尽管这种异常的原因尚不清楚，但似乎包括遗传和免疫起源，可能受到特殊的潜在疾病和某些产科情况的影响。前列腺素失衡（特别是前列环素和血栓素A2）似乎是控制这些异常的主要因素之一。这些机制的后果之一是高血压的发作，但其他紊乱也是基本特征。特别是，可能会发生弥散性血管内凝血，导致大量微血栓形成，从而引起胎盘病变（导致慢性胎儿窘迫）、肾脏、肝脏和脑部病变。
