Sulka Agnieszka, Simon Krzysztof, Piszko Paweł, Kalecińska Ewa, Dominiak Marzena
Department of Oral Surgery, Medical University in Wrocław, Poland.
Bull Group Int Rech Sci Stomatol Odontol. 2006 Mar;47(1):6-10.
The aim of the study was to evaluate the character of lesions within oral mucosa in patients suffering from chronic hepatitis and cirrhosis of the liver due to either HBV or HCV infection. A total of 74 patients treated at the Clinic of Infectious Diseases in Wrocław for chronic hepatitis B (20 patients, group I) and for chronic hepatitis C (23 patients group III) and cirrhosis of the liver due to HBV (15 patients , group II) and HCV (16 patients, group IV) infection. The control group comprised 29 healthy subjects. Lesions within the oral mucosa found on clinical examinations were confirmed with a histopathological evaluation. Patients suffering from chronic hepatitis B revealed leukoplakia (1/20), melanoplakia (1/20), petechiae (1/20), 17 patients from this group did not show any changes. Patients suffering from chronic hepatitis C revealed leukoplakia (6/23), Delbanco's disease (2/23), melanoplakia (1/23), lichen planus (1/23), petechiae (1/23), 12 patients from this group did not show any changes. Patients suffering from cirrhosis of the liver due of HBV infection revealed leukoplakia (3/15) petechiae (2/15), Delbanco's disease (1/15), angular cheilitis (1/15), aphthae (1/15), 7 patients from this group did not reveal any changes. Patients suffering from cirrhosis of the liver due of HCV infection revealed petechiae (2/16), melanoplakia (1/16), candidosis (1/16), labial herpes (1/16), 11 patients from this group did not reveal any changes. In control group we observed leukoplakia (3/29), Delbanco's disease (1/29), labial herpes (1/29), petechiae (1/29), and 23 subjects did not present pathological lesions within the oral mucosa. Results indicate the lack of connection between chronic HBV and HCV infection as well as the stage of the disease with the incidence and character of oral lesions in oral mucosa.
本研究的目的是评估因乙肝病毒（HBV）或丙肝病毒（HCV）感染而患有慢性肝炎和肝硬化的患者口腔黏膜内病变的特征。共有74例患者在弗罗茨瓦夫传染病诊所接受治疗，其中20例为慢性乙型肝炎患者（第一组），23例为慢性丙型肝炎患者（第三组），15例为因HBV感染导致肝硬化的患者（第二组），16例为因HCV感染导致肝硬化的患者（第四组）。对照组包括29名健康受试者。临床检查发现的口腔黏膜病变通过组织病理学评估得以证实。慢性乙型肝炎患者出现白斑（1/20）、黑斑（1/20）、瘀点（1/20），该组17例患者未出现任何变化。慢性丙型肝炎患者出现白斑（6/23）、德尔班科病（2/23）、黑斑（1/23）、扁平苔藓（1/23）、瘀点（1/23），该组12例患者未出现任何变化。因HBV感染导致肝硬化的患者出现白斑（3/15）、瘀点（2/15）、德尔班科病（1/15）、口角炎（1/15）、口疮（1/15），该组7例患者未出现任何变化。因HCV感染导致肝硬化的患者出现瘀点（2/16）、黑斑（1/16）、念珠菌病（1/16）、唇疱疹（1/16），该组11例患者未出现任何变化。在对照组中，我们观察到白斑（3/29）、德尔班科病（1/29）、唇疱疹（1/29）、瘀点（1/29），23名受试者口腔黏膜未出现病理性病变。结果表明，慢性HBV和HCV感染以及疾病阶段与口腔黏膜病变的发生率和特征之间不存在关联。
