Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
J Public Health Dent. 2009 Summer;69(3):168-75. doi: 10.1111/j.1752-7325.2009.00119.x.
Our purpose was to carry out an epidemiological study to assess the prevalence of oral mucosal conditions in Brazilian patients with chronic hepatitis C.
A cross-sectional survey was carried out on 215 patients with chronic hepatitis C who were examined for oral mucosal conditions, including oral mucosal lesions and variations of normality.
The prevalence of patients with chronic hepatitis C presenting oral mucosal conditions was 96.3 percent (207 patients). Oral mucosal lesions were present in 147 patients (68.4 percent), whereas variations of normality were observed in 173 patients (80.5 percent). The most common lesions included cheek biting in 42 cases (19.5 percent), candidiasis in 39 cases (18.1 percent), and leukoplakia in 28 cases (13.0 percent). The association of oral lichen planus with hepatitis C virus (HCV) infection proved to be statistically significant (P = 0.002). The most frequent variations of normality included Fordyce's spots in 96 cases (44.7 percent), lingual varicosities in 67 cases (31.2 percent), and fissured tongue in 60 cases (27.9 percent).
The prevalence of patients with chronic hepatitis C presenting oral mucosal conditions was 96.3 percent. Despite this high prevalence, only the association between oral lichen planus and hepatitis C showed statistical significance. Considering that HCV infection may be associated with extrahepatic disorders, such as oral manifestations, efforts should be made to clarify the possible relation between oral conditions and HCV infection. This may be helpful in the earlier diagnosis of the infection mainly in asymptomatic patients.
我们旨在进行一项流行病学研究，以评估巴西慢性丙型肝炎患者口腔黏膜状况的流行情况。
对 215 例慢性丙型肝炎患者进行了横断面调查，检查了口腔黏膜状况，包括口腔黏膜病变和正常变异。
慢性丙型肝炎患者口腔黏膜状况的患病率为 96.3%（207 例）。147 例患者存在口腔黏膜病变（68.4%），173 例患者存在正常变异（80.5%）。最常见的病变包括颊咬 42 例（19.5%）、念珠菌病 39 例（18.1%）和白斑 28 例（13.0%）。口腔扁平苔藓与丙型肝炎病毒（HCV）感染的相关性具有统计学意义（P = 0.002）。最常见的正常变异包括福代斯斑点 96 例（44.7%）、舌静脉曲张 67 例（31.2%）和裂纹舌 60 例（27.9%）。
慢性丙型肝炎患者口腔黏膜状况的患病率为 96.3%。尽管患病率较高，但只有口腔扁平苔藓与丙型肝炎之间存在统计学意义。鉴于 HCV 感染可能与肝外疾病有关，如口腔表现，应努力阐明口腔状况与 HCV 感染之间的可能关系。这可能有助于在主要是无症状患者中早期诊断感染。
