Sitaram N, Wyatt R J, Dawson S, Gillin J C
Science. 1976 Mar 26;191(4233):1281-3. doi: 10.1126/science.176724.
Physostigmine (an anticholinesterase agent that increases acetylcholine at the synapse), in a dose of 0.5 milligram, was given intravenously to seven normal human volunteers. When injected during rapid eye movement (REM) sleep, physostigmine woke the subjects, and when injected during non-REM sleep, it induced REM sleep. This result suggests that cholinergic mechanisms play a role in the induction of REM sleep and in modulating cortical arousal mechanisms.
给7名正常人类志愿者静脉注射0.5毫克毒扁豆碱（一种增加突触中乙酰胆碱的抗胆碱酯酶剂）。在快速眼动（REM）睡眠期间注射时，毒扁豆碱会唤醒受试者，而在非快速眼动睡眠期间注射时，它会诱发快速眼动睡眠。这一结果表明，胆碱能机制在快速眼动睡眠的诱导以及调节皮层唤醒机制中发挥作用。
