Gillin J C, Sitaram N, Mendelson W B, Wyatt R J
Psychopharmacology (Berl). 1978 Jun 15;58(1):111-4. doi: 10.1007/BF00426799.
Physostigmine (1.0mg) or placebo were administered intravenously over 1-h period to seven male normal volunteers beginning 35 min after sleep onset. The results indicate that physostigmine induced the onset of REM sleep but did not significantly alter the duration of individual REM sleep periods. Physostigmine significantly shortened the REM latency and the duration of the second nonREM period. After inducing the onset of the first REM period(s); physostigmine also appeared to advance succeeding REM-nonREM sleep cycles relative to sleep onset even when the duration of each cycle was unaffected.
从睡眠开始35分钟后，对7名男性正常志愿者在1小时内静脉注射毒扁豆碱（1.0毫克）或安慰剂。结果表明，毒扁豆碱可诱发快速眼动睡眠的开始，但并未显著改变各个快速眼动睡眠期的时长。毒扁豆碱显著缩短了快速眼动睡眠潜伏期和第二个非快速眼动期的时长。在诱发第一个快速眼动期开始后，即使每个周期的时长未受影响，毒扁豆碱似乎也使随后的快速眼动 - 非快速眼动睡眠周期相对于睡眠开始时间提前。
