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在正确的地方探寻睡眠:我的睡眠研究职业生涯。

Searching for sleep in all the right places: My career in sleep research.

作者信息

Shiromani Priyattam J

机构信息

Laboratory of Sleep Medicine and Chronobiology, Ralph H. Johnson Veterans Healthcare System, Charleston, SC, USA.

Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA.

出版信息

Sleep Adv. 2024 Aug 29;5(1):zpae055. doi: 10.1093/sleepadvances/zpae055. eCollection 2024.

Abstract

My research has always focused on sleep, whether monitoring neural activity (microwires, c-Fos, calcium imaging), triggering it with optogenetics or pharmacologically (anandamide, cholinergic agonists), or measuring levels of endogenous sleep agents such as adenosine. A recurring theme of my research is to use new tools to find the sweet spot in the brain where the signal to sleep begins. My goal is to identify the circuit, determine whether it degrades with age or disease, and repair the circuit when it fails. I am deeply grateful to my mentors for introducing me to the science of sleep, to my students and colleagues for helping me in my quest, and to the NIH and VA Research for supporting the research. Because of the collective efforts of sleep researchers, the public is more aware of the importance of sleep to a healthy lifestyle.

摘要

我的研究一直聚焦于睡眠,无论是监测神经活动(微丝、c-Fos、钙成像),通过光遗传学或药理学方法(花生四烯乙醇胺、胆碱能激动剂)触发睡眠,还是测量内源性睡眠介质如腺苷的水平。我研究中反复出现的一个主题是使用新工具来找到大脑中睡眠信号起始的最佳位置。我的目标是识别该神经回路,确定其是否会随着年龄增长或疾病而退化,并在其出现故障时修复该神经回路。我非常感谢我的导师们引领我进入睡眠科学领域,感谢我的学生和同事们在我的探索过程中给予帮助,也感谢美国国立卫生研究院和退伍军人事务部研究部门对这项研究的支持。由于睡眠研究人员的共同努力,公众更加意识到睡眠对健康生活方式的重要性。

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本文引用的文献

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