Xia Yin-yin, Zhan Si-yan
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100083, China.
Zhonghua Jie He He Hu Xi Za Zhi. 2007 Jun;30(6):419-23.
To study the incidences of adverse reactions induced by anti-tuberculosis drugs in China.
Articles about adverse drug reactions (ADR) induced by anti-tuberculosis drugs published in 1996 - 2005 in China were searched. The incidences, possible risk factors, and prognoses of these ADR were analyzed.
According to our searching strategy and including criteria, 117 studies were included. The overall incidence of anti-tuberculosis drug induced ADR of these studies was 12.62%, and the overall incidence of hepatic injury was 11.9%, which was the highest among all kinds of ADR induced by anti-tuberculosis therapy. For different types of study, different diagnostic standards of hepatic injury, and different study institutions, the reported incidences of hepatic injury varied. Retrospective cohort studies showed that HBV(+) tuberculosis patients had a significantly higher risk of hepatic injury than HBV(-) patients. The prognosis of hepatic injury was good; 85.84% patients were cured of hepatic injury according to the articles which reported outcomes. The whole study was finished by 2006.
The incidence of adverse reactions induced by anti-tuberculosis drugs is high in China. Prevention and treatment of ADR are very important for improving the adherence of patients.
研究我国抗结核药物所致不良反应的发生率。
检索1996年至2005年国内发表的有关抗结核药物引起的药物不良反应（ADR）的文章。分析这些ADR的发生率、可能的危险因素及预后。
按照检索策略和纳入标准，共纳入117项研究。这些研究中抗结核药物所致ADR的总发生率为12.62%，肝损伤的总发生率为11.9%，在抗结核治疗引起的各类ADR中最高。不同类型的研究、不同的肝损伤诊断标准以及不同的研究机构，所报道的肝损伤发生率有所不同。回顾性队列研究表明，乙肝病毒（HBV）阳性的结核病患者发生肝损伤的风险显著高于HBV阴性患者。肝损伤的预后良好；根据报道结局的文章，85.84%的患者肝损伤治愈。整个研究于2006年完成。
我国抗结核药物所致不良反应的发生率较高。ADR的防治对于提高患者的依从性非常重要。
