Holmes Rebecca J, Cohen Paula E
Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA.
Chromosome Res. 2007;15(5):653-65. doi: 10.1007/s10577-007-1144-z.
RNA interference is involved in many aspects of cell biology, and the recent identification of germ-cell specific small RNAs has led to speculation that RNAi might also be involved in gametogenesis. Work in yeast indicates that RNAi is involved in establishing and maintaining heterochromatin at centromeres, an important component of yeast and mammalian meiosis. Here we review developments in the field of RNAi and relate these to possible roles in mammalian gametogenesis.
RNA干扰参与细胞生物学的多个方面，最近对生殖细胞特异性小RNA的鉴定引发了人们的猜测，即RNA干扰可能也参与配子发生。酵母研究表明，RNA干扰参与在着丝粒处建立和维持异染色质，着丝粒是酵母和哺乳动物减数分裂的重要组成部分。在此，我们综述RNA干扰领域的进展，并将其与在哺乳动物配子发生中的可能作用联系起来。
