Laboratory of Systems Biology and Bioinformatics, Institute of Biochemistry and Biophysics and COE in Biomathematics, University of Tehran, Iran.
Funct Integr Genomics. 2011 Sep;11(3):389-405. doi: 10.1007/s10142-011-0236-1. Epub 2011 Jul 22.
In this review, the pathways involving small RNAs are provided followed by a new and updated network that illustrates their interplay with diverse cellular mechanisms in Caenorhabditis elegans. The RNA silencing pathways are now recognized as key factors that connect together the many variations in biological processes, including transcriptional gene regulation, post-transcriptional gene silencing, translational gene silencing, apoptosis, meiosis, and antiviral defense. The utilization of small RNAs represents a specific, energy conserving, and fast mechanism of gene regulation via a core system known as RNA interference.
在这篇综述中，提供了涉及小 RNA 的途径，随后展示了一个新的和更新的网络，说明了它们在秀丽隐杆线虫中与多种细胞机制的相互作用。RNA 沉默途径现在被认为是连接包括转录基因调控、转录后基因沉默、翻译基因沉默、细胞凋亡、减数分裂和抗病毒防御在内的许多生物过程变化的关键因素。小 RNA 的利用代表了一种通过称为 RNA 干扰的核心系统进行基因调控的特定、节能和快速的机制。
