Kishimoto Miori, Yamada Kazutaka, Watanabe Asuka, Miyamoto Kenji, Iwasaki Toshiroh, Miyake Yoh-Ichi
Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-Sen 11, Inada-cho, Obihiro, Hokkaido 080-8555, Japan.
J Vet Med Sci. 2007 Jul;69(7):713-5. doi: 10.1292/jvms.69.713.
In excretory urography, the osmolarity of contrast media has rarely been treated as important in veterinary medicine. In this study, the contrast effect of two contrast media (monomeric iohexol and dimeric iodixanol) in the renal cortex and aorta were compared using computed tomography (CT). Five beagle dogs were used and the study employed a cross-over method for each contrast media. The results showed that there was no difference between the media in the aorta, but iodixanol showed higher CT value and a longer contrast effect than iohexol in the renal cortex, in spite of having the same iodine dosage. It is believed that iodixanol, with its low osmolarity, is diluted less by osmotic diuresis than monomeric iohexol. It is important to consider the osmolarity of the contrast media when evaluating the contrast effect, and it is essential to use the same contrast media for each examination, or the renal excretory speed will be under/overestimated.
在排泄性尿路造影中，造影剂的渗透压在兽医学中很少被视为重要因素。在本研究中，使用计算机断层扫描（CT）比较了两种造影剂（单体碘海醇和二聚体碘克沙醇）在肾皮质和主动脉中的造影效果。使用了5只比格犬，该研究对每种造影剂采用了交叉方法。结果表明，两种造影剂在主动脉中的表现无差异，但尽管碘克沙醇和碘海醇的碘剂量相同，但在肾皮质中，碘克沙醇的CT值更高，造影效果持续时间更长。据信，低渗透压的碘克沙醇比单体碘海醇受渗透性利尿的稀释作用更小。在评估造影效果时，考虑造影剂的渗透压很重要，并且每次检查必须使用相同的造影剂，否则肾排泄速度将被低估或高估。
