Shin Eun-Kyung, Jung Rose, Hahn Tae-Wook
School of Veterinary Medicine, Kangwon National University, Chuncheon, Kangwon-Do, 200-701, Republic of Korea.
J Vet Med Sci. 2007 Jul;69(7):771-4. doi: 10.1292/jvms.69.771.
Bordetella bronchiseptica pertactin (prn) is an outer membrane protein which has been implicated as both an adhesin and a protective antigen that induces immunity against atrophic rhinitis in pigs. Previous studies demonstrated extensive heterogeneity of the prn sequence within two distinct regions of amino acid repeats for B. bronchiseptica isolated from the United States and Europe. By deducing the amino acid sequences of the repeat regions of the prn gene from recent isolates from Korea, two region 1 variants and five region 2 variants were identified. Five pertactin types were distinguished based on combinations of variants of both regions. Interestingly, none of the field isolates have the same pertactin type as the B. bronchiseptica P4 strain widely used to vaccinate pigs.
支气管败血波氏杆菌黏附素（prn）是一种外膜蛋白，它被认为既是一种黏附素，也是一种保护性抗原，可诱导猪对萎缩性鼻炎产生免疫力。先前的研究表明，从美国和欧洲分离出的支气管败血波氏杆菌的prn序列在两个不同的氨基酸重复区域内存在广泛的异质性。通过推导来自韩国的近期分离株的prn基因重复区域的氨基酸序列，鉴定出了两个1型变体和五个2型变体。根据两个区域变体的组合区分出了五种黏附素类型。有趣的是，没有一株田间分离株具有与广泛用于给猪接种疫苗的支气管败血波氏杆菌P4菌株相同的黏附素类型。
