Boursaux-Eude C, Guiso N
Laboratoire des Bordetella, Institut Pasteur, 75724 Paris, France.
Infect Immun. 2000 Aug;68(8):4815-7. doi: 10.1128/IAI.68.8.4815-4817.2000.
Pertactin is an outer membrane protein expressed by Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica that induces protective immunity to Bordetella infections. The immunodominant and immunoprotective epitopes of pertactin include two repeated regions, I and II. Comparison of these two repeated regions showed that B. parapertussis pertactin is invariant, whereas B. pertussis pertactin varies mostly in region I and B. bronchiseptica pertactin varies in both repeated regions I and II, but mostly in region II. These differences may result from specific characteristics of these Bordetella species.
百日咳杆菌粘附素是一种由百日咳博德特氏菌、副百日咳博德特氏菌和支气管败血博德特氏菌表达的外膜蛋白,可诱导针对博德特氏菌感染的保护性免疫。百日咳杆菌粘附素的免疫显性和免疫保护性表位包括两个重复区域,即区域I和区域II。对这两个重复区域的比较表明,副百日咳博德特氏菌的百日咳杆菌粘附素是不变的,而百日咳博德特氏菌的百日咳杆菌粘附素主要在区域I发生变化,支气管败血博德特氏菌的百日咳杆菌粘附素在重复区域I和区域II均有变化,但主要在区域II。这些差异可能源于这些博德特氏菌物种的特定特征。