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Novel genetic and phenotypic heterogeneity in Bordetella bronchiseptica pertactin.支气管败血波氏杆菌黏附素中的新型遗传和表型异质性。
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Misidentification of Bordetella bronchiseptica as Bordetella pertussis using a newly described real-time PCR targeting the pertactin gene.使用一种新描述的针对百日咳杆菌黏附素基因的实时聚合酶链反应将支气管败血博德特氏菌误鉴定为百日咳博德特氏菌。
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Nat Genet. 2003 Sep;35(1):32-40. doi: 10.1038/ng1227. Epub 2003 Aug 10.
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Cloning, nucleotide sequence and heterologous expression of the protective outer-membrane protein P.68 pertactin from Bordetella bronchiseptica.支气管败血波氏杆菌保护性外膜蛋白P.68菌毛蛋白的克隆、核苷酸序列及异源表达
J Gen Microbiol. 1992 Aug;138 Pt 8:1697-705. doi: 10.1099/00221287-138-8-1697.

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Novel genetic and phenotypic heterogeneity in Bordetella bronchiseptica pertactin.支气管败血波氏杆菌黏附素中的新型遗传和表型异质性。
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本文引用的文献

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Intranasal murine model of Bordetella pertussis infection: II. Sequence variation and protection induced by a tricomponent acellular vaccine.百日咳博德特氏菌感染的鼻内小鼠模型：II. 三组分无细胞疫苗诱导的序列变异与保护作用
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Human but not ovine isolates of Bordetella parapertussis are highly clonal as determined by PCR-based RAPD fingerprinting.基于聚合酶链反应的随机扩增多态性DNA指纹图谱分析表明，百日咳博德特氏菌的人源分离株具有高度克隆性，而羊源分离株则不然。
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Polymorphism in the Bordetella pertussis virulence factors P.69/pertactin and pertussis toxin in The Netherlands: temporal trends and evidence for vaccine-driven evolution.荷兰百日咳博德特氏菌毒力因子69kDa外膜蛋白/丝状血凝素和百日咳毒素的多态性：时间趋势及疫苗驱动进化的证据
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百日咳博德特氏菌、副百日咳博德特氏菌和支气管败血博德特氏菌中丝状血凝素重复区域的多态性

Polymorphism of repeated regions of pertactin in Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica.

作者信息

Boursaux-Eude C, Guiso N

机构信息

Laboratoire des Bordetella, Institut Pasteur, 75724 Paris, France.

出版信息

Infect Immun. 2000 Aug;68(8):4815-7. doi: 10.1128/IAI.68.8.4815-4817.2000.

DOI:10.1128/IAI.68.8.4815-4817.2000
PMID:10899896
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC98445/
Abstract

Pertactin is an outer membrane protein expressed by Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica that induces protective immunity to Bordetella infections. The immunodominant and immunoprotective epitopes of pertactin include two repeated regions, I and II. Comparison of these two repeated regions showed that B. parapertussis pertactin is invariant, whereas B. pertussis pertactin varies mostly in region I and B. bronchiseptica pertactin varies in both repeated regions I and II, but mostly in region II. These differences may result from specific characteristics of these Bordetella species.

摘要

百日咳杆菌粘附素是一种由百日咳博德特氏菌、副百日咳博德特氏菌和支气管败血博德特氏菌表达的外膜蛋白，可诱导针对博德特氏菌感染的保护性免疫。百日咳杆菌粘附素的免疫显性和免疫保护性表位包括两个重复区域，即区域I和区域II。对这两个重复区域的比较表明，副百日咳博德特氏菌的百日咳杆菌粘附素是不变的，而百日咳博德特氏菌的百日咳杆菌粘附素主要在区域I发生变化，支气管败血博德特氏菌的百日咳杆菌粘附素在重复区域I和区域II均有变化，但主要在区域II。这些差异可能源于这些博德特氏菌物种的特定特征。