Doherty M K, McLean L, Beynon R J
Protein Function Group, Department of Veterinary Preclinical Sciences, University of Liverpool, Liverpool, UK.
Cytogenet Genome Res. 2007;117(1-4):358-69. doi: 10.1159/000103199.
Proteomics is defined as an analysis of the full complement of proteins of a cell or tissue under given conditions. Avian proteomics, or more specifically chicken proteomics, has focussed on the study of individual tissues and organs of interest to specific researchers. Researchers have looked at skeletal muscle and growth, and embryonic development and have performed initial studies in avian disease. Traditional proteomics involves identifying and cataloguing proteins in a cell and identifying relative changes in populations between two or more states, be that physiological or disease-induced states. Recent advances in proteomic technologies have included absolute quantification, proteome simplification and the ability to determine the turnover of individual proteins in a global context. This review discusses the current developments in this relatively new field, new technologies and how they may be applied to biological questions, and the challenges faced by researchers in this ever-expanding and exciting field.
蛋白质组学的定义是对特定条件下细胞或组织中的全部蛋白质进行分析。禽类蛋白质组学，或者更具体地说是鸡蛋白质组学，一直专注于特定研究人员感兴趣的单个组织和器官的研究。研究人员研究了骨骼肌与生长、胚胎发育，并开展了禽类疾病的初步研究。传统蛋白质组学包括识别和编目细胞中的蛋白质，以及识别两种或更多种状态（无论是生理状态还是疾病诱导状态）下蛋白质群体的相对变化。蛋白质组学技术的最新进展包括绝对定量、蛋白质组简化以及在整体背景下确定单个蛋白质周转的能力。本综述讨论了这个相对较新领域的当前发展、新技术及其如何应用于生物学问题，以及研究人员在这个不断扩展且令人兴奋的领域中面临的挑战。
