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形状记忆聚合物泡沫动脉瘤治疗技术的血管动力学

Vascular dynamics of a shape memory polymer foam aneurysm treatment technique.

作者信息

Ortega Jason, Maitland Duncan, Wilson Tom, Tsai William, Savaş Omer, Saloner David

机构信息

Engineering, Lawrence Livermore National Laboratory, P.O. Box 808, L-644, Livermore, CA 94551, USA.

出版信息

Ann Biomed Eng. 2007 Nov;35(11):1870-84. doi: 10.1007/s10439-007-9358-y. Epub 2007 Aug 4.

Abstract

The vascular dynamics of a shape memory polymer foam aneurysm treatment technique are assessed through the simulated treatment of a generic basilar aneurysm using coupled fluid dynamics and heat transfer calculations. The shape memory polymer foam, which expands to fill the aneurysm when heated, is modeled at three discrete stages of the treatment procedure. To estimate an upper bound for the maximum amount of thermal damage due to foam heating, a steady velocity is specified through the basilar artery, corresponding to a minimum physiological flow velocity over a cardiac cycle. During expansion, the foam alters the flow patterns within the aneurysm by shielding the aneurysm dome from a confined jet that issues from the basilar artery. The time scales for thermal damage to the artery walls and surrounding blood flow are computed from the temperature field. The flow through the post-treatment bifurcation is comprised of two counter-rotating vortex tubes that are located beneath the aneurysm neck and extend downstream into the outlet arteries. Beneath the aneurysm neck, a marked increase in the wall shear stress is observed due to the close proximity of the counter-rotating vortex tubes to the artery wall.

摘要

通过使用耦合流体动力学和传热计算对一般基底动脉瘤进行模拟治疗,评估形状记忆聚合物泡沫动脉瘤治疗技术的血管动力学。形状记忆聚合物泡沫在加热时会膨胀以填充动脉瘤,在治疗过程的三个离散阶段对其进行建模。为了估计由于泡沫加热导致的最大热损伤量的上限,通过基底动脉指定一个稳定速度,该速度对应于心周期内的最小生理流速。在膨胀过程中,泡沫通过将动脉瘤穹顶与从基底动脉发出的受限射流隔离开来,改变动脉瘤内的流动模式。根据温度场计算动脉壁和周围血流的热损伤时间尺度。治疗后分叉处的血流由两个反向旋转的涡管组成,它们位于动脉瘤颈部下方并向下游延伸至出口动脉。在动脉瘤颈部下方,由于反向旋转的涡管与动脉壁非常接近,观察到壁面剪应力显著增加。

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