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迈向神经记忆芯片：在培养的神经网络中印记多个记忆

Towards neuro-memory-chip: imprinting multiple memories in cultured neural networks.

作者信息

Baruchi Itay, Ben-Jacob Eshel

机构信息

School of Physics and Astronomy, Raymond & Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel-Aviv, Israel.

出版信息

Phys Rev E Stat Nonlin Soft Matter Phys. 2007 May;75(5 Pt 1):050901. doi: 10.1103/PhysRevE.75.050901. Epub 2007 May 16.

DOI:10.1103/PhysRevE.75.050901
PMID:17677014
Abstract

We show that using local chemical stimulations it is possible to imprint persisting (days) multiple memories (collective modes of neuron firing) in the activity of cultured neural networks. Microdroplets of inhibitory antagonist are injected at a location selected based on real-time analysis of the recorded activity. The neurons at the stimulated locations turn into a focus for initiating synchronized bursting events (the collective modes) each with its own specific spatiotemporal pattern of neuron firing.

摘要

我们表明，通过使用局部化学刺激，有可能在培养的神经网络活动中印记持续（数天）的多个记忆（神经元放电的集体模式）。基于对记录活动的实时分析，在选定位置注入抑制性拮抗剂微滴。受刺激位置的神经元会变成引发同步爆发事件（集体模式）的焦点，每个事件都有其自身特定的神经元放电时空模式。

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