Detti Laura, Yelian Frank D, Kruger Michael L, Diamond Michael P, Rode Anuradha, Mitwally Mohamed F M, Puscheck Elizabeth E
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
Fertil Steril. 2008 Apr;89(4):998-1001. doi: 10.1016/j.fertnstert.2007.04.027. Epub 2007 Aug 6.
In this retrospective cohort study of 102 ovarian stimulation cycles for IVF/intracytoplasmic sperm injection using GnRH antagonist and gonadotropins, we sought to assess the effect of high E(2) levels on endometrial stripe thickness and its association with pregnancy outcomes and serum E(2) levels. We found no significant correlation between serum E(2) levels (both peak and area under the curve E(2) concentration) and the endometrial thickness. However, there was a statistically significant inverse relationship with early pregnancy loss (31%) if the endometrial thickness was <9.8 mm (sensitivity 71%; specificity 76%).
在这项针对102个使用促性腺激素释放激素拮抗剂和促性腺激素进行体外受精/卵胞浆内单精子注射的卵巢刺激周期的回顾性队列研究中，我们试图评估高雌二醇（E₂）水平对子宫内膜厚度的影响及其与妊娠结局和血清E₂水平的关联。我们发现血清E₂水平（峰值和曲线下面积E₂浓度）与子宫内膜厚度之间无显著相关性。然而，如果子宫内膜厚度<9.8 mm，早期妊娠丢失率为31%，存在统计学上显著的负相关关系（敏感性71%；特异性76%）。
