Cook R J, Neerhut R, Thomas D G
Department of Anaesthesia, St. Vincent's Hospital, Melbourne, Australia.
Anaesth Intensive Care. 1991 Aug;19(3):357-64. doi: 10.1177/0310057X9101900308.
The efficacy of epidural fentanyl combined with lignocaine 1.5% with adrenaline 1:200,000 was studied in a randomised, double-blind, controlled trial of two hundred patients undergoing extracorporeal shock wave lithotripsy with or without ancillary procedures. The quality of anaesthesia was assessed using linear analogue pain scores, the patient's impression, and the rate of intra-operative intervention by the anaesthetist. Postoperative symptomatology was also recorded. The only significant difference lay postoperatively in that the fentanyl-ancillary procedure sub-group had less pain approximately one hour postoperatively (P = 0.01). In the context of this study and in the presence of an adequate autonomic and somatic local anaesthetic blockade, the addition of epidural fentanyl does not appear to confer any significant advantage other than to enhance postoperative analgesia.
在一项针对200例接受体外冲击波碎石术(无论有无辅助手术)的患者的随机、双盲、对照试验中,研究了硬膜外注射芬太尼联合含1:200,000肾上腺素的1.5%利多卡因的疗效。使用线性模拟疼痛评分、患者的主观感受以及麻醉医生的术中干预率来评估麻醉质量。还记录了术后症状。唯一显著的差异在于术后,芬太尼-辅助手术亚组在术后约1小时疼痛较轻(P = 0.01)。在本研究的背景下,以及在存在充分的自主神经和躯体局部麻醉阻滞的情况下,除增强术后镇痛效果外,添加硬膜外芬太尼似乎并未带来任何显著优势。