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对帕金森病中使用假手术的证据的批判性分析:对公共卫生的影响。

A critical analysis of evidence for using sham surgery in Parkinson's disease: implications for public health.

作者信息

Polgar Stephen, Ng Joanna

机构信息

School of Public Health, Faculty of Health Sciences, La Trobe University, Kingsbury Drive, Bundoora, Victoria 3086.

出版信息

Aust N Z J Public Health. 2007 Jun;31(3):270-4. doi: 10.1111/j.1467-842x.2007.00060.x.

DOI:10.1111/j.1467-842x.2007.00060.x
PMID:17679247
Abstract

Sham surgery was introduced as a means for improving the methodological quality of surgical research and evaluation. The development of cellular-based surgical therapies for the treatment of Parkinson's disease provides an opportunity to carefully analyse the alleged methodological benefits of sham surgery. However, detailed analysis of the evidence does not support these hypothesised advantages. In this paper, we argue that sham surgery is a public health concern as vulnerable individuals are exposed to unnecessary and costly surgical procedures that have no benefits for ensuring rigorous health research.

摘要

假手术作为一种提高外科研究和评估方法质量的手段而被引入。用于治疗帕金森病的基于细胞的外科治疗方法的发展为仔细分析假手术所谓的方法学益处提供了契机。然而,对证据的详细分析并不支持这些假设的优势。在本文中,我们认为假手术是一个公共卫生问题,因为易受伤害的个体要接受不必要且昂贵的外科手术,而这些手术对确保严谨的健康研究并无益处。

相似文献

1
A critical analysis of evidence for using sham surgery in Parkinson's disease: implications for public health.对帕金森病中使用假手术的证据的批判性分析:对公共卫生的影响。
Aust N Z J Public Health. 2007 Jun;31(3):270-4. doi: 10.1111/j.1467-842x.2007.00060.x.
2
Evidence-Based Evaluation of the Ethics of Sham Surgery for Parkinson's Disease.基于证据的假性帕金森手术伦理评估。
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Placebos that harm: sham surgery controls in clinical trials.有害的安慰剂:临床试验中的假手术对照
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What is the risk of sham surgery in Parkinson disease clinical trials? A review of published reports.帕金森病临床试验中假手术的风险是什么?对已发表报告的综述。
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What is the risk of sham surgery in Parkinson disease clinical trials? A review of published reports.帕金森病临床试验中假手术的风险是什么?对已发表报告的综述。
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Sham neurosurgery in patients with Parkinson's disease: is it morally acceptable?帕金森病患者的假神经外科手术:在道德上可接受吗?
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引用本文的文献

1
Strengthening the ethical assessment of placebo-controlled surgical trials: three proposals.加强安慰剂对照手术试验的伦理评估:三项提议。
BMC Med Ethics. 2014 Oct 23;15:78. doi: 10.1186/1472-6939-15-78.
2
CD90 Expression on human primary cells and elimination of contaminating fibroblasts from cell cultures.CD90 在人原代细胞上的表达及细胞培养中对成纤维细胞污染的清除。
Cytotechnology. 2009 Jan;59(1):31-44. doi: 10.1007/s10616-009-9190-3. Epub 2009 Mar 19.
3
Potential cellular and regenerative approaches for the treatment of Parkinson's disease.
治疗帕金森病的潜在细胞和再生方法。
Neuropsychiatr Dis Treat. 2008 Oct;4(5):835-45. doi: 10.2147/ndt.s2013.