Sisson D, Schaeffer D
Department of Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana 61801.
Am J Vet Res. 1991 Oct;52(10):1591-6.
The growth of the heart, relative to body weight, was measured by M-mode echocardiography in dogs during the first year of life. Echocardiographic measurements were obtained from 16 English Pointers at 1, 2, 4, and 8 weeks of age and at 3, 6, 9, and 12 months of age. Left atrial (LA), aortic (AO), left and right ventricular internal dimensions, interventricular septal and left ventricular wall thickness measurements increased in curvilinear fashion relative to increasing body weight. Least-squares regression analysis, performed on logarithmically transformed data, was used to develop power-law equations describing the relationship of echocardiographic measurements to body weight. Linear dimensions of the LA, AO, left and right ventricular internal dimensions and interventricular septal and left ventricular wall thickness changed proportionally to slightly differing exponential powers of body weight (BW), varying from 0.31 to 0.45 (BW0.31 to BW0.45). Fractional shortening and the LA to AO ratio decreased slightly, but significantly, as body weight increased. Indexing echocardiographic measurements to BW1/3 was more appropriate than indexing such measures linearly to body weight, offering a practical method for developing accurate normative graphs or tables for M-mode echocardiographic dimensions in growing dogs.
在犬出生后的第一年，通过M型超声心动图测量心脏重量相对于体重的增长情况。对16只英国指示犬在1周、2周、4周、8周龄以及3个月、6个月、9个月和12个月龄时进行超声心动图测量。左心房（LA）、主动脉（AO）、左心室和右心室内径、室间隔及左心室壁厚度测量值相对于体重增加呈曲线增长。对经对数转换的数据进行最小二乘回归分析，以建立描述超声心动图测量值与体重关系的幂律方程。LA、AO、左心室和右心室内径以及室间隔和左心室壁厚度的线性尺寸与体重（BW）的指数幂成比例变化，指数幂略有不同，范围从0.31至0.45（BW0.31至BW0.45）。随着体重增加，缩短分数和LA与AO比值略有但显著下降。将超声心动图测量值以BW1/3为指标比以体重线性为指标更合适，为建立生长犬M型超声心动图尺寸的准确标准图表提供了一种实用方法。
