[雌激素受体β基因Rsa I、Alu I多态性与不明原因月经过少的关系研究]

[The study on the relationship between Rsa I, Alu I polymorphism of the estrogen receptor beta gene and unknown aetiology hypomenorrhea].

作者信息

Yuan Rui, Le Ai-wen, Gen Li, Xia En-lan, Yao Zhen-wei

机构信息

Department of Obstetrics and Gynecology, the Affiliated First Hospital, Chongqing University of Medical Sciences, Chongqing, 400016 P. R. China.

出版信息

Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007 Aug;24(4):425-7.

PMID:17680534

Abstract

OBJECTIVE

To study the relationship between estrogen receptor beta gene (ER beta) polymorphism and unknown aetiology hypomenorrhea in Southwestern China .

METHODS

One hundred eumenorrhea women were chosen as control group and another 100 hypomenorrhea patients as case group from Southwestern China. Restriction fragment length polymorphism (RFLP) of the Rsa I and Alu I in ER beta gene was analysed. The ER beta gene polymorphism genotype distribution in case group and control group was compared.

RESULTS

R allele frequency in case and control groups was 37.5% and 48.5% respectively, the OR was 0.64 (95%CI: 0.42-0.97), P= 0.026. A allele frequency in case and control groups was 18.0% and 11.5% respectively, the OR was 1.69 (95%CI: 0.93-3.09), P= 0.07. RFLP of Rsa I and Alu I in both groups were distributed with polymorphism.

CONCLUSION

ERbeta gene polymorphism has a relation with unknown aetiological hypomenorrhea. R allele may be the guard factor, and A allele may be its risk factor.

摘要

目的

研究雌激素受体β基因（ERβ）多态性与中国西南地区不明原因月经过少的关系。

方法

选取中国西南地区100例月经正常女性作为对照组，另选100例月经过少患者作为病例组。分析ERβ基因中Rsa I和Alu I的限制性片段长度多态性（RFLP）。比较病例组和对照组中ERβ基因多态性基因型分布。

结果

病例组和对照组中R等位基因频率分别为37.5%和48.5%，OR为0.64（95%CI：0.42 - 0.97），P = 0.026。病例组和对照组中A等位基因频率分别为18.0%和11.5%，OR为1.69（95%CI：0.93 - 3.09），P = 0.07。两组中Rsa I和Alu I的RFLP均呈多态性分布。