Kupka Ralph W, Altshuler Lori L, Nolen Willem A, Suppes Trisha, Luckenbaugh David A, Leverich Gabriele S, Frye Mark A, Keck Paul E, McElroy Susan L, Grunze Heinz, Post Robert M
Altrecht Institute for Mental Health Care, Utrecht, The Netherlands.
Bipolar Disord. 2007 Aug;9(5):531-5. doi: 10.1111/j.1399-5618.2007.00467.x.
To assess the proportion of time spent in mania, depression and euthymia in a large cohort of bipolar subjects studied longitudinally, and to investigate depression/mania ratios in patients with bipolar I versus bipolar II disorder.
Clinician-adjusted self-ratings of mood were completed daily for one year for naturalistically treated outpatients with bipolar I (n = 405) or bipolar II (n = 102) disorder. Ratings were analyzed for mean time spent euthymic, depressed, manic, hypomanic, and cycling, and the percentages of time spent ill were compared between the two groups.
Percentages of time spent ill for bipolar I versus II patients were: euthymia 47.7% versus 50.2%; depression 36.0% versus 37.0%; hypomania 11.5% versus 9.8%; mania 1.0% versus 0.2%; and cycling 3.7% versus 2.8%. The depression/mania ratio was 2.9 in the bipolar I and 3.8 in bipolar II sub-groups.
Depression represents the predominant abnormal mood state for treated outpatients with bipolar I and II disorder. In contrast to other studies, we found that depression/mania ratios were of a similar magnitude, suggesting the same tendency towards mood instability in both sub-groups.
评估一大群接受纵向研究的双相情感障碍患者处于躁狂、抑郁和心境正常状态的时间比例，并调查双相I型障碍与双相II型障碍患者的抑郁/躁狂比率。
对405例双相I型障碍或102例双相II型障碍的自然治疗门诊患者进行为期一年的每日临床医生调整后的情绪自评。分析评分以确定处于心境正常、抑郁、躁狂、轻躁狂和循环状态的平均时间，并比较两组患者患病时间的百分比。
双相I型与双相II型患者患病时间的百分比分别为：心境正常47.7%对50.2%；抑郁36.0%对37.0%；轻躁狂11.5%对9.8%；躁狂1.0%对0.2%；循环3.7%对2.8%。双相I型亚组的抑郁/躁狂比率为2.9，双相II型亚组为3.8。
抑郁是双相I型和II型障碍接受治疗门诊患者的主要异常情绪状态。与其他研究不同，我们发现抑郁/躁狂比率相似，表明两个亚组都有相同的情绪不稳定倾向。
