自闭症更广泛的语言表型：与特定语言障碍的比较。
The broader language phenotype of autism: a comparison with specific language impairment.
作者信息
Whitehouse Andrew J O, Barry Johanna G, Bishop Dorothy V M
机构信息
University of Oxford, UK.
出版信息
J Child Psychol Psychiatry. 2007 Aug;48(8):822-30. doi: 10.1111/j.1469-7610.2007.01765.x.
BACKGROUND
Some individuals with autism spectrum disorders (ASD) experience linguistic difficulties similar to those found in individuals with specific language impairment (SLI). Whether these behaviours are indicative of a common underlying genetic cause or a superficial similarity is unclear.
METHODS
Standardised language assessments were administered to three participant groups: parents of children with ASD (Par-A), parents of children with specific language/literacy impairment (Par-L) and parents of typically developing children (Par-T) (n = 30, in each group). Additionally, the Autism-Spectrum Quotient (AQ) was used to assess autism-like tendencies, in particular, social language use.
RESULTS
The Par-A group performed better than the Par-L group (and identical to the Par-T group) on all language tests. Conversely, the Par-A group was characterised by higher levels of pragmatic difficulties than the other two groups, as measured by the communication subscale of the AQ.
CONCLUSIONS
No evidence was found for a shared phenotype in parents of children with ASD and SLI. A model is presented describing the relation between SLI and ASD.
背景
一些自闭症谱系障碍（ASD）患者存在与特定语言障碍（SLI）患者类似的语言困难。尚不清楚这些行为是由共同的潜在遗传原因导致，还是仅为表面上的相似。
方法
对三个参与者组进行标准化语言评估：ASD儿童的父母（Par-A组）、特定语言/读写障碍儿童的父母（Par-L组）和发育正常儿童的父母（Par-T组）（每组n = 30）。此外，使用自闭症谱系商数（AQ）来评估类似自闭症的倾向，特别是社交语言使用情况。
结果
在所有语言测试中，Par-A组的表现优于Par-L组（与Par-T组相同）。相反，根据AQ的沟通分量表测量，Par-A组的语用困难水平高于其他两组。
结论
未发现ASD儿童和SLI儿童的父母存在共同表型的证据。本文提出了一个描述SLI与ASD之间关系的模型。
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