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恐惧条件反射后乳头体、丘脑前核和背侧海马中c-Fos表达的诱导。

Induction of c-Fos expression in the mammillary bodies, anterior thalamus and dorsal hippocampus after fear conditioning.

作者信息

Conejo Nélida M, González-Pardo Héctor, López Matías, Cantora Raúl, Arias Jorge L

机构信息

Laboratory of Neuroscience, Faculty of Psychology, University of Oviedo, Plaza Feijoo, s/n, E-33003 Oviedo, Spain.

出版信息

Brain Res Bull. 2007 Sep 14;74(1-3):172-7. doi: 10.1016/j.brainresbull.2007.06.006. Epub 2007 Jul 3.

Abstract

The aim of the present study was to provide further evidence on the role of particular subdivisions of the mammillary bodies, anterior thalamus and dorsal hippocampus to contextual and auditory fear conditioning. We used c-Fos expression as a marker of neuronal activation to compare rats that received tone-footshock pairings in a distinctive context (conditioned group) to rats being exposed to both the context and the auditory CS without receiving footshocks (unconditioned group), and naïve rats that were only handled. Fos immunoreactivity was significantly increased only in the anterodorsal thalamic nucleus and the lateral mammillary nucleus of the conditioned group. However, the dorsal hippocampus showed the highest density of c-Fos positive nuclei in the naïve group as compared to the other groups. Together, our data support previous studies indicating a particular involvement of the mammillary bodies and anterior thalamus in fear conditioning.

摘要

本研究的目的是进一步提供证据,证明乳头体、丘脑前核和背侧海马体的特定亚区在情境性和听觉恐惧条件反射中的作用。我们使用c-Fos表达作为神经元激活的标志物,将在独特情境中接受音调-电击配对的大鼠(条件反射组)与暴露于该情境和听觉条件刺激但未接受电击的大鼠(非条件反射组)以及仅经过处理的未经验大鼠进行比较。仅在条件反射组的丘脑前背核和外侧乳头核中,Fos免疫反应性显著增加。然而,与其他组相比,未经验大鼠组的背侧海马体中c-Fos阳性核的密度最高。总之,我们的数据支持先前的研究,表明乳头体和丘脑前核在恐惧条件反射中具有特殊作用。

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