Bolte H, Riedel C, Müller-Hülsbeck S, Freitag-Wolf S, Kohl G, Drews T, Heller M, Biederer J
Department of Diagnostic Radiology, University Hospital Schleswig-Holstein Campus Kiel, Arnold-Heller Strasse 9, 24105 Kiel, Germany.
Br J Radiol. 2007 Jun;80(954):414-21. doi: 10.1259/bjr/23933268.
The purpose of this study was to investigate the precision of CT-based volumetric measurements of artificial small pulmonary nodules under ex vivo conditions. We implanted 322 artificial nodules in 23 inflated ex vivo porcine lungs in a dedicated chest phantom. The lungs were examined with a multislice spiral CT (20 mAs, collimation 16x0.75 mm, 1 mm slice thickness, 0.7 mm increment). A commercial volumetry software package (LungCARE VA70C-W; Siemens, Erlangen, Germany) was used for volume analysis in a semi-automatic and a manual corrected mode. After imaging, the lungs were dissected to harvest the nodules for gold standard determination. The volumes of 202 solitary, solid and well-defined lesions without contact with the pleura, greater bronchi or vessels were compared with the results of volumetry. A mean nodule diameter of 8.3 mm (+/-2.1 mm) was achieved. The mean relative deviation from the true lesion volume was -9.2% (+/-10.6%) for semi-automatic and -0.3% (+/-6.5%) for manual corrected volumetry. The subgroup of lesions from 5 mm to <10 mm in diameter showed a mean relative deviation of -8.7% (+/-10.9%) for semi-automatic volumetry and -0.3% (+/-6.9%) for manually corrected volumetry. We conclude that the presented software allowed for precise volumetry of artificial nodules in ex vivo lung tissue. This result is comparable to the findings of previous in vitro studies.
本研究的目的是调查体外条件下基于CT的人工小肺结节体积测量的精度。我们在一个专用胸部模型中的23个离体充气猪肺中植入了322个人工结节。使用多层螺旋CT（20 mAs，准直16×0.75 mm，层厚1 mm，层间距0.7 mm）对肺进行检查。使用一个商业体积分析软件包（LungCARE VA70C-W；西门子，德国埃尔朗根）以半自动和手动校正模式进行体积分析。成像后，解剖肺以获取结节用于金标准测定。将202个孤立、实性且边界清晰、未与胸膜、较大支气管或血管接触的病变的体积与体积测量结果进行比较。平均结节直径为8.3 mm（±2.1 mm）。半自动体积测量与真实病变体积的平均相对偏差为-9.2%（±10.6%），手动校正体积测量为-0.3%（±6.5%）。直径从5 mm至<10 mm的病变亚组，半自动体积测量的平均相对偏差为-8.7%（±10.9%），手动校正体积测量为-0.3%（±6.9%）。我们得出结论，所展示的软件能够对离体肺组织中的人工结节进行精确的体积测量。这一结果与先前体外研究的结果相当。
