Kelley Darshan S, Siegel David, Vemuri Madhuri, Mackey Bruce E
Western Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, University of California Davis, CA 95616-8683, USA.
Am J Clin Nutr. 2007 Aug;86(2):324-33. doi: 10.1093/ajcn/86.2.324.
The effects of docosahexaenoic acid (DHA) on the mean size and concentrations of VLDL, LDL, and HDL subclasses have not been previously studied.
We determined the effects of DHA supplementation on the concentrations of apoproteins; large, medium, and small VLDL, LDL, and HDL particles; and the mean diameters of these particles in fasting and postprandial plasma.
Hypertriglyceridemic men aged 39-66 y (n = 34) participated in a double-blind, randomized, placebo-controlled parallel study. They received no supplements for the first 8 d and received either 7.5 g DHA oil/d (3 g DHA/d) or olive oil (placebo) for the last 90 d. Lipoprotein particle diameters and concentrations were measured by nuclear magnetic resonance spectroscopy.
DHA supplementation for 45 d significantly (P < 0.05) decreased concentrations of fasting triacylglycerol (24%), large VLDL (92%), and intermediate-density lipoproteins (53%) and the mean diameter of VLDL particles (11.1 nm). It elevated concentrations of LDL cholesterol (12.6%), small VLDL particles (133%), and large LDL particles (120%) and the mean diameter of LDL particles (0.6 nm) in fasting plasma. Similar changes were observed for area under the curve for postprandial samples (0-6 h); however, the number of small dense LDL particles decreased significantly (21%), and the change in LDL cholesterol was not significant. Continued supplementation with DHA beyond 45 d caused no further changes; placebo treatment altered none of the responses tested.
DHA supplementation may improve cardiovascular health by lowering concentrations of triacylglycerols and small, dense LDL particles.
此前尚未研究二十二碳六烯酸（DHA）对极低密度脂蛋白（VLDL）、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）亚类的平均大小及浓度的影响。
我们测定了补充DHA对载脂蛋白浓度、大、中、小VLDL、LDL和HDL颗粒以及空腹和餐后血浆中这些颗粒平均直径的影响。
39 - 66岁的高甘油三酯血症男性（n = 34）参与了一项双盲、随机、安慰剂对照平行研究。他们在最初8天不补充任何物质，在最后90天接受7.5克DHA油/天（3克DHA/天）或橄榄油（安慰剂）。通过核磁共振波谱法测量脂蛋白颗粒直径和浓度。
补充DHA 45天显著（P < 0.05）降低了空腹甘油三酯浓度（24%）、大VLDL浓度（92%）和中密度脂蛋白浓度（53%）以及VLDL颗粒的平均直径（11.1纳米）。它提高了空腹血浆中LDL胆固醇浓度（12.6%）、小VLDL颗粒浓度（133%）和大LDL颗粒浓度（120%）以及LDL颗粒的平均直径（0.6纳米）。餐后样本（0 - 6小时）曲线下面积也观察到类似变化；然而，小而密LDL颗粒数量显著减少（21%），LDL胆固醇的变化不显著。45天后继续补充DHA没有引起进一步变化；安慰剂治疗对所测试的任何反应均无影响。
补充DHA可能通过降低甘油三酯和小而密LDL颗粒的浓度来改善心血管健康。
