Perren Aurel, Anlauf Martin, Komminoth Paul
Department of Pathology, University Hospital Zürich, Zurich, Switzerland.
Virchows Arch. 2007 Aug;451 Suppl 1:S39-46. doi: 10.1007/s00428-007-0449-9. Epub 2007 Aug 8.
Neuroendocrine tumors of the gastroenteropancreatic system are defined by their endocrine phenotype and share many histopathological and clinical features. However, the fact that the hormone production of tumors depends on their site of origin, that the tumors differ in their biology, and that the association with familial syndromes is nonrandom suggests heterogeneity. It is therefore conceivable that the gastroenteropancreatic neuroendocrine tumors also differ in their molecular profile. This review summarizes and discusses the available data in this field.
胃肠胰系统神经内分泌肿瘤由其内分泌表型定义，并具有许多组织病理学和临床特征。然而，肿瘤的激素产生取决于其起源部位、肿瘤在生物学上存在差异以及与家族综合征的关联并非随机，这些事实表明存在异质性。因此，可以想象胃肠胰神经内分泌肿瘤在分子特征上也存在差异。本综述总结并讨论了该领域的现有数据。
