Rozgonyi F, Kocsis E, Kristóf K, Nagy K
Clin Microbiol Infect. 2007 Sep;13(9):843-5. doi: 10.1111/j.1469-0691.2007.01780.x.
Numerous clinical studies have indicated, based on mortality rates, that methicillin-resistant Staphylococcus aureus (MRSA) strains are more virulent than methicillin-susceptible S. aureus (MSSA) strains. In contrast, quantitative laboratory examinations of the presence and magnitude of pathogenic mechanisms and virulence factors in strains of MRSA and MSSA have generated conflicting data. The most important reason for these conflicting results is probably the heterogeneic nature of the resistant population. A comparison of selected and congenic MRSA and MSSA sub-populations of the same strain is required to resolve this issue.
众多临床研究基于死亡率表明，耐甲氧西林金黄色葡萄球菌（MRSA）菌株比甲氧西林敏感金黄色葡萄球菌（MSSA）菌株的毒性更强。相比之下，对MRSA和MSSA菌株中致病机制和毒力因子的存在情况及程度进行的定量实验室检测得出了相互矛盾的数据。这些相互矛盾结果的最重要原因可能是耐药菌群的异质性。需要对同一菌株的选定同基因MRSA和MSSA亚群进行比较，以解决这个问题。
