Christensen T
Institute of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark.
Int MS J. 2006 May;13(2):52-7.
Environmental factors operate on a background of genetic susceptibility in the pathogenesis of MS. Human herpesviruses, notably Epstein-Barr virus (EBV), and human endogenous retroviruses are factors associated with MS. EBV association is found in epidemiological surveys where late EBV infection confers a higher risk of MS, and EBV reactivation also appears to be linked to disease activity in early MS. MS patients have elevated anti-EBV antibody responses, both in serum and cerebrospinal fluid. Molecular mimicry is found between certain EBV and myelin epitopes in the cell-mediated immune response. EBV cannot stand alone as a causal factor of MS, but is likely to play an indirect role as an activator of the underlying disease process.
在多发性硬化症（MS）的发病机制中，环境因素在遗传易感性的背景下起作用。人类疱疹病毒，尤其是爱泼斯坦-巴尔病毒（EBV），以及人类内源性逆转录病毒是与MS相关的因素。在流行病学调查中发现了EBV关联，其中晚期EBV感染会增加患MS的风险，而且EBV再激活似乎也与早期MS的疾病活动有关。MS患者血清和脑脊液中的抗EBV抗体反应均升高。在细胞介导的免疫反应中，某些EBV和髓磷脂表位之间存在分子模拟。EBV不能单独作为MS的致病因素，但可能作为潜在疾病过程的激活剂发挥间接作用。
