Grassi Guido, Arenare Francesca, Trevano Fosca Quarti, Dell'Oro Raffaella, Mancia And Giuseppe
Clinica Medica, Ospedale S. Gerardo, Università Milano Bicocca, Via Pergolesi 33, 20052, Monza (Milan), Italy.
Curr Hypertens Rep. 2007 Aug;9(4):299-304. doi: 10.1007/s11906-007-0055-x.
High blood pressure represents one of the leading risk factors for the development of stroke and its recurrence. This explains why blood pressure control is a major objective of antihypertensive treatment, both in primary and secondary prevention of this cerebrovascular disease. This paper reviews the evidence provided by randomized clinical trials on the favorable effects exerted by blood pressure reduction on this end point. Emphasis is given to the results of recently published clinical trials documenting that drugs acting on the renin-angiotensin system may exert cerebrovascular protective effects additive to the ones associated with blood pressure reduction.
高血压是中风发生及其复发的主要危险因素之一。这就解释了为什么血压控制是抗高血压治疗的主要目标，无论是在这种脑血管疾病的一级预防还是二级预防中。本文回顾了随机临床试验提供的证据，这些证据表明血压降低对这一终点具有有益作用。重点关注最近发表的临床试验结果，这些结果表明作用于肾素-血管紧张素系统的药物可能具有除与血压降低相关的脑血管保护作用之外的额外保护作用。
