Suppr超能文献

印度加尔各答女性性工作者中HIV-1包膜蛋白基因和负调控因子基因的亚型间重组体检测

Detection of intersubtype recombinants with respect to env and nef genes of HIV-1 among female sex workers in Calcutta, India.

作者信息

Bhanja Payel, Sengupta Satarupa, Banerjee Debjani, Sarkar Kamalesh, Jana Smarajit, Chakrabarti Sekhar

机构信息

HIV/AIDS Laboratory, National Institute of Cholera and Enteric Diseases, P-33, C.I.T. Road, Scheme-XM, Beliaghata, Calcutta, India.

出版信息

Virus Res. 2007 Dec;130(1-2):310-4. doi: 10.1016/j.virusres.2007.06.013. Epub 2007 Aug 7.

Abstract

HIV-1 detected among female sex workers in Calcutta, India was characterized in respect to env and nef genes. A total of 39 HIV-1 seropositive samples were used in the study. Phylogenetic analysis of the nucleotide sequences of respective regions showed that 22 out of 39 samples (56.4%) were infected with subtype C with respect to both env and nef genes; however, 17 samples (43.6%) showed distinct subtype discordance. Simplot analysis of these samples showed the presence of intersubtype recombination between subtypes C and B. Both env C/nef B and env B/nef C recombinants were found to be present; 16 samples were found to be env C/nef B and 1 sample was detected as env B/nef C. This result indicates the emergence of intersubtype recombinants of HIV-1 for the first time in this eastern part of India.

摘要

对印度加尔各答女性性工作者中检测出的HIV-1进行了env和nef基因特征分析。该研究共使用了39份HIV-1血清阳性样本。对各区域核苷酸序列的系统发育分析表明,39份样本中有22份(56.4%)在env和nef基因方面均感染了C亚型;然而,17份样本(43.6%)表现出明显的亚型不一致。对这些样本的Simplot分析显示C亚型和B亚型之间存在亚型间重组。发现同时存在env C/nef B和env B/nef C重组体;16份样本为env C/nef B,1份样本检测为env B/nef C。这一结果表明在印度东部首次出现了HIV-1亚型间重组体。

相似文献

1
Detection of intersubtype recombinants with respect to env and nef genes of HIV-1 among female sex workers in Calcutta, India.
Virus Res. 2007 Dec;130(1-2):310-4. doi: 10.1016/j.virusres.2007.06.013. Epub 2007 Aug 7.
2
Emergence of new forms of human immunodeficiency virus type 1 intersubtype recombinants in central Myanmar.
AIDS Res Hum Retroviruses. 2000 Nov 20;16(17):1831-43. doi: 10.1089/08892220050195793.
4
Novel HIV-1 long terminal repeat (LTR) sequences of subtype B and mosaic intersubtype B/C recombinants in North India.
Arch Virol. 2008;153(10):1961-6. doi: 10.1007/s00705-008-0210-y. Epub 2008 Sep 26.
7
The changing trend of HIV type 1 subtypes in Nairobi.
AIDS Res Hum Retroviruses. 2009 Mar;25(3):337-42. doi: 10.1089/aid.2008.0228.
10
Circulation of HIV-1 subtype A within the subtype C HIV-1 epidemic in Tamil Nadu, India.
J Med Virol. 2012 Oct;84(10):1507-13. doi: 10.1002/jmv.23383.

引用本文的文献

1
Insights into human immunodeficiency virus-hepatitis B virus co-infection in India.
World J Virol. 2015 Aug 12;4(3):255-64. doi: 10.5501/wjv.v4.i3.255.
2
HIV infection in India: epidemiology, molecular epidemiology and pathogenesis.
J Biosci. 2008 Nov;33(4):515-25. doi: 10.1007/s12038-008-0070-3.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验