印度泰米尔纳德邦 HIV-1 流行株 C 内 HIV-1 亚型 A 的循环。

Circulation of HIV-1 subtype A within the subtype C HIV-1 epidemic in Tamil Nadu, India.

机构信息

Department of Experimental Medicine, Tamil Nadu Dr MGR Medical University, Chennai, Tamil Nadu, India.

出版信息

J Med Virol. 2012 Oct;84(10):1507-13. doi: 10.1002/jmv.23383.

Abstract

The HIV-1 epidemic in India is caused mainly by subtype C viruses that are transmitted sexually and by injecting drug use. The state of Tamil Nadu in Southern India has an HIV-1 median prevalence of 16.8% among injecting drug users, 6.6% in men who have sex with men, and 4.6% in female sex workers. In the rural district of Namakkal, a prevalence >3% was detected among antenatal women. The goal of this study was to determine the HIV-1 molecular epidemiology in Tamil Nadu. Blood samples were collected from 40 high-risk HIV-seropositive individuals from Chennai and Namakkal. HIV-1 subtype was determined by envelope nucleotide sequencing. Among the samples studied, 85% were subtype C, however, a cluster of subtype A samples (12.5%) and one subtype E recombinant form CRF01_AE (close to the Thailand strains) were detected. The average genetic distance of subtype C samples from Chennai and Namakkal were 9.44 ± 0.77% and 11.8 ± 0.7%, respectively indicating an evolved epidemic. This pilot study confirmed that subtype C was predominant in these regions but an outbreak of subtype A was detected in Namakkal. These results stress the importance of periodic monitoring of circulating HIV-1 subtypes in South India.

摘要

印度的 HIV-1 疫情主要由性传播和注射吸毒传播的 C 型病毒引起。印度南部的泰米尔纳德邦，注射吸毒者中 HIV-1 的中位流行率为 16.8%，男男性行为者中为 6.6%，性工作者中为 4.6%。在 Namakkal 农村地区，产前妇女中的流行率>3%。本研究的目的是确定泰米尔纳德邦的 HIV-1 分子流行病学。从钦奈和 Namakkal 的 40 名高危 HIV 血清阳性个体中采集血液样本。通过包膜核苷酸测序确定 HIV-1 亚型。在所研究的样本中，85%为 C 型，但检测到一组 A 型样本（12.5%）和一种 E 型重组形式 CRF01_AE（与泰国株接近）。来自钦奈和 Namakkal 的 C 型样本的平均遗传距离分别为 9.44±0.77%和 11.8±0.7%，表明疫情已经演变。这项初步研究证实，C 型在这些地区占主导地位，但在 Namakkal 检测到 A 型爆发。这些结果强调了定期监测印度南部流行的 HIV-1 亚型的重要性。