Lommatzsch P K, Lommatzsch R
University Eye Hospital, Leipzig, Germany.
Br J Ophthalmol. 1991 Dec;75(12):715-7. doi: 10.1136/bjo.75.12.715.
Thirty nine patients suffering from juxtapapillary choroidal melanoma were treated with Ru-106/Rh-106 beta-ray plaques. The tumoricidal dose was 100 Gy at the apex of the tumour within 7-14 days. Additional photocoagulation was performed in 12 eyes. The irradiated eyes of three patients had to be enucleated, seven patients died, five of them (12.8%) from metastases. Thirty two (82%) patients are alive and 29 (74%) have a seeing eye. From the whole series 20 (51%) developed flat scars and 11 (29%) patients retained a visual acuity of 0.5-1.0. Radiogenic late complications with damage to the optic nerve and macula were the main causes of visual deterioration.
39例患视乳头旁脉络膜黑色素瘤的患者接受了Ru-106/Rh-106β射线敷贴器治疗。肿瘤杀灭剂量为在7至14天内肿瘤顶端达到100 Gy。12只眼进行了额外的光凝治疗。3例患者的照射眼不得不被摘除,7例患者死亡,其中5例(12.8%)死于转移。32例(82%)患者存活,29例(74%)保留有用视力。整个系列中20例(51%)出现扁平瘢痕,11例(29%)患者视力保持在0.5至1.0。对视神经和黄斑造成损害的放射性晚期并发症是视力恶化的主要原因。