用于脉络膜恶性黑色素瘤治疗的改良碘-125敷贴器设计
Improved iodine-125 plaque design in the treatment of choroidal malignant melanoma.
作者信息
Hill J C, Sealy R, Shackleton D, Stannard C, Korrubel J, Hering E, Loxton C
机构信息
Department of Ophthalmology, Groote Schuur Hospital.
出版信息
Br J Ophthalmol. 1992 Feb;76(2):91-4. doi: 10.1136/bjo.76.2.91.
Abstract
The use and development of iodine-125 plaque therapy for choroidal malignant melanoma are described. Since 1975 experience has led to changes in plaque design and insertion techniques. Twenty-one patients were irradiated with local episcleral iodine-125 plaques. Three patients required a second plaque for tumour recurrence. Four eyes were enucleated because of continued tumour growth and a further eye was removed because of glaucoma secondary to radiation retinopathy. Two patients (9.5%) died of metastases. The remaining 19 patients are alive and clinically clear of metastases, with a mean follow up time of 73.1 months (range 43-142 months).
摘要
本文描述了碘-125敷贴疗法在脉络膜恶性黑色素瘤治疗中的应用与发展。自1975年以来，经验促使敷贴器设计和植入技术发生了变化。21例患者接受了局部巩膜外碘-125敷贴器照射。3例患者因肿瘤复发需要第二次使用敷贴器。4只眼因肿瘤持续生长而被摘除，另有1只眼因放射性视网膜病变继发青光眼而被摘除。2例患者（9.5%）死于转移。其余19例患者存活，临床上无转移迹象，平均随访时间为73.1个月（范围43 - 142个月）。
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