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芬格用于放射治疗的“开缝式”眼内斑块:视乳头旁和视乳头周围眼内肿瘤的治疗

Finger's "slotted" eye plaque for radiation therapy: treatment of juxtapapillary and circumpapillary intraocular tumours.

作者信息

Finger Paul T

机构信息

The New York Eye Cancer Centre, 115 East 61st Street, New York City, NY 10065, USA.

出版信息

Br J Ophthalmol. 2007 Jul;91(7):891-4. doi: 10.1136/bjo.2007.114082. Epub 2007 Feb 27.

Abstract

AIM

To create "slotted eye plaques" for the treatment of juxtapapillary and circumpapillary intraocular tumours.

METHODS

Eye plaques were altered such that 8 mm-wide slots (variable length) were created to accommodate the orbital portion of the optic nerve. Thus, as the nerve entered the slot, the plaque's posterior margin extended beyond the optic disc. Radioactive seeds were affixed around the slot, surrounding the juxtapapillary and posterior tumour margins.

RESULTS

As proof of principle, three patients with choroidal melanomas that encircled or were in contact with the optic disc (considered untreatable with a notched eye plaque) were considered to be initial candidates for slotted-plaque radiotherapy. Preoperative three-dimensional C-scan imaging of their optic nerve sheath diameters insured that they would fit in the slotted plaque. Intraoperative ultrasound imaging was used to confirm proper plaque placement. Radiation dosimetry modelling showed that all tumour tissue received a minimum of 85 Gy (despite the gap created by the slot). With relatively short-term follow-up, there has been no evidence of ocular ischaemia, tumour growth or complications attributable to the use of slotted-plaque radiation therapy.

CONCLUSION

Slotted plaques accommodate the retrobulbar optic nerve into the device and thereby shift the treatment zone to improve coverage of both juxtapapillary and circumpapillary intraocular tumours.

摘要

目的

制作“带槽眼敷贴器”用于治疗视乳头旁和视乳头周围的眼内肿瘤。

方法

对视敷贴器进行改造,制作出8毫米宽的槽(长度可变)以容纳视神经的眶内部分。这样,当神经进入槽内时,敷贴器的后缘延伸至视盘之外。放射性籽源固定在槽的周围,环绕视乳头旁和肿瘤后缘。

结果

作为原理验证,三名脉络膜黑色素瘤环绕或接触视盘(被认为无法用带缺口眼敷贴器治疗)的患者被视为带槽敷贴器放射治疗的初始候选者。术前对其视神经鞘直径进行三维C扫描成像,确保他们适合使用带槽敷贴器。术中使用超声成像确认敷贴器放置正确。放射剂量学建模显示,所有肿瘤组织至少接受了85 Gy的辐射(尽管槽造成了间隙)。经过相对短期的随访,没有证据表明存在眼部缺血、肿瘤生长或因使用带槽敷贴器放射治疗引起的并发症。

结论

带槽敷贴器将球后视神经纳入装置,从而转移治疗区域,以改善对视乳头旁和视乳头周围眼内肿瘤的覆盖。

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