Packer S, Rotman M, Fairchild R G, Albert D M, Atkins H L, Chan B
Arch Ophthalmol. 1980 Aug;98(8):1453-7. doi: 10.1001/archopht.1980.01020040305019.
Radioactive iodine 125 is a low-energy gamma isotope with physical characteristics suitable for irradiation of intraocular tumors. Metal ophthalmic applicators have been designed to shield vital ocular structures while allowing irradiation of the tumor. We compared the radiation effects of iodine 125 and cobalt 60. The Greene melanoma was transplanted into the suprachoroidal space of rabbits. The tumor then grew as an intraocular mass, was irradiated, and was followed up for two months before enucleation. Histopathologic examination defined the extent of the radiation damage to the tumor and other ocular structures from the iodine 125 and from the cobalt 60. The eye irradiated with iodine 125 suffered minimal radiation damage, whereas the tumor was sterilized. The eye irradiated with cobalt 60 showed substantial radiation damage, and the melanoma was incompletely treated. Our results support the use of iodine 125 in treating intraocular tumors. More research is needed as to optimum total dose and dose rate.
放射性碘125是一种低能γ同位素，其物理特性适合用于眼内肿瘤的照射。金属眼科施源器的设计目的是在允许肿瘤接受照射的同时，屏蔽眼内重要结构。我们比较了碘125和钴60的辐射效果。将格林氏黑色素瘤移植到兔眼脉络膜上腔。肿瘤随后作为眼内肿物生长，接受照射，并在摘除眼球前随访两个月。组织病理学检查确定了碘125和钴60对肿瘤及其他眼内结构的辐射损伤程度。接受碘125照射的眼睛遭受的辐射损伤最小，而肿瘤被彻底消除。接受钴60照射的眼睛显示出严重的辐射损伤，黑色素瘤未得到完全治疗。我们的结果支持使用碘125治疗眼内肿瘤。关于最佳总剂量和剂量率，还需要更多研究。
