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一名支气管扩张患者发生铜绿假单胞菌脉络膜脓肿。

Pseudomonas aeruginosa choroidal abscess in a patient with bronchiectasis.

作者信息

Li Kenneth K W, Tang Emily W H, Lai Jimmy S M, Wong David

机构信息

Eye Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam road, Hong Kong SAR, China.

出版信息

Int Ophthalmol. 2008 Aug;28(4):287-90. doi: 10.1007/s10792-007-9126-x. Epub 2007 Aug 9.

Abstract

PURPOSE

To report a case of Pseudomonas aeruginosa endophthalmitis with choroidal abscess formation in a patient with bronchiectasis.

METHODS

Case report.

RESULTS

A 75-year-old gentleman with bronchiectasis and P. aeruginosa pneumonia developed painless loss of right eye vision. The patient had previously undergone bronchoscopy to exclude pulmonary neoplasm. Slit-lamp examination revealed intense anterior chamber inflammation with hypopyon and B-scan ophthalmic ultrasound showed a choroidal mass consistent with choroidal abscess. Systemic and topical antibiotics did not prevent further progression of the infection. Patient declined pars plana vitrectomy and opted for enucleation. Polymerase-chain-reaction-based restriction fragment-length polymorphism (PCR-RFLP) of the enucleated eye confirmed P. aeruginosa to be the causative organism.

CONCLUSION

P. aeruginosa cannot be completely eradicated by systemic antibiotics, and bronchial colonization of P. aeruginosa can remain a potential source for metastatic infection. P. aeruginosa choroidal abscess, previously reported only in patients with cystic fibrosis, can also occur in bronchiectasis. Physicians should therefore have a high index of suspicion of endogenous endophthalmitis and treat aggressively, especially in patients with subretinal invasion and abscess formation.

摘要

目的

报告一例支气管扩张患者发生铜绿假单胞菌性眼内炎并伴有脉络膜脓肿形成的病例。

方法

病例报告。

结果

一名75岁患有支气管扩张和铜绿假单胞菌肺炎的男性患者出现右眼无痛性视力丧失。该患者此前接受过支气管镜检查以排除肺部肿瘤。裂隙灯检查显示前房有强烈炎症并伴有前房积脓,B超眼部超声检查显示有一个与脉络膜脓肿相符的脉络膜肿物。全身及局部使用抗生素未能阻止感染的进一步发展。患者拒绝行玻璃体切割术,选择了眼球摘除术。对摘除眼球进行基于聚合酶链反应的限制性片段长度多态性分析(PCR-RFLP)证实铜绿假单胞菌为病原体。

结论

全身抗生素不能完全根除铜绿假单胞菌,支气管内铜绿假单胞菌定植可能仍是转移性感染的潜在来源。铜绿假单胞菌脉络膜脓肿以前仅在囊性纤维化患者中报道过,也可发生于支气管扩张患者。因此,医生对内源性眼内炎应保持高度怀疑并积极治疗,尤其是在有视网膜下侵犯和脓肿形成的患者中。

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