Kaburaki Toshikatsu, Takamoto Mitsuko, Araki Fumiyuki, Fujino Yujiro, Nagahara Miyuki, Kawashima Hidetoshi, Numaga Jiro
Department of Ophthalmology, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Int Ophthalmol. 2010 Apr;30(2):203-6. doi: 10.1007/s10792-009-9304-0. Epub 2009 Apr 10.
We report a case of Candida albicans endophthalmitis with subretinal abscess formation in a patient who underwent liver transplantation.
Case report.
A 51-year-old Japanese woman complained of deep pain and ciliary injection in her right eye. Three months prior, the patient had undergone liver transplantation for cirrhosis caused by hepatitis C. A slit-lamp examination revealed intense anterior chamber inflammation with hypopyon and fundoscopy showed a yellowish-white subretinal mass lesion in the inferior peripheral fundus. Systemic and topical antibiotics did not prevent further progression of the infection. The patient underwent pars plana vitrectomy treatment three times and a histopathological study of a vitreous specimen revealed C. albicans to be the causative organism.
A subretinal abscess, previously reported in Nocardia, Pseudomonas, Staphylococcus, and Aspergillus infection cases, can also occur in patients infected with Candida. Therefore, Candida infection should be considered as a potential cause of subretinal abscess in organ transplant recipients.
我们报告一例肝移植患者发生白色念珠菌性眼内炎并形成视网膜下脓肿的病例。
病例报告。
一名51岁的日本女性主诉右眼深部疼痛和睫状充血。三个月前，该患者因丙型肝炎导致的肝硬化接受了肝移植。裂隙灯检查显示前房炎症剧烈伴前房积脓，眼底镜检查显示周边眼底下方有黄白色视网膜下肿块病变。全身及局部使用抗生素未能阻止感染的进一步发展。该患者接受了三次玻璃体切割术治疗，玻璃体标本的组织病理学研究显示白色念珠菌为病原体。
视网膜下脓肿此前在诺卡菌、铜绿假单胞菌、葡萄球菌和曲霉菌感染病例中已有报道，在念珠菌感染患者中也可能发生。因此，念珠菌感染应被视为器官移植受者视网膜下脓肿的潜在病因。
