Léna J Y, Sri Widada J, Ferraz C, Liautard J P, Rabié A, Faivre-Sarrailh C
Laboratoire de Neurobiologie Endocrinologique, URA 1197 CNRS, Université Montpellier II-Sciences et Techniques du Languedoc, France.
Neuroreport. 1991 Mar;2(3):117-20. doi: 10.1097/00001756-199103000-00001.
Profilin and profilin mRNA concentrations were determined in the cerebellum of the developing rat. Profilin represented nearly 0.1% of total Triton-soluble protein both at birth and at the end of the developmental period. During brain maturation, the profilin concentration was regulated at the transcriptional level. A transient increase of profilin mRNA and profilin was observed at the end of the first postnatal week, a period of intense cell proliferation, neuritic outgrowth and synaptogenesis. We propose that profilin may act by forming, during the critical period of cerebellar development, a reserve pool of monomeric actin that can easily be mobilized in cell regions such as growth cones or synaptic junctions where filamentous actin is highly concentrated.
在发育中的大鼠小脑内测定了肌动蛋白单体结合蛋白（profilin）和肌动蛋白单体结合蛋白mRNA的浓度。出生时以及发育期末，肌动蛋白单体结合蛋白占Triton可溶蛋白总量的近0.1%。在脑成熟过程中，肌动蛋白单体结合蛋白的浓度在转录水平受到调控。在出生后第一周结束时，即细胞大量增殖、神经突生长和突触形成的时期，观察到肌动蛋白单体结合蛋白mRNA和肌动蛋白单体结合蛋白出现短暂增加。我们提出，在小脑发育的关键时期，肌动蛋白单体结合蛋白可能通过形成一个单体肌动蛋白储备池来发挥作用，该储备池能够在丝状肌动蛋白高度浓缩的细胞区域（如生长锥或突触连接）轻易地被调动。
