Finkler Aliza, Ashery-Padan Ruth, Fromm Hillel
Department of Plant Sciences, Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
FEBS Lett. 2007 Aug 21;581(21):3893-8. doi: 10.1016/j.febslet.2007.07.051. Epub 2007 Aug 1.
Recently, a novel family of calmodulin-binding transcription activators (CAMTAs) was reported in various eukaryotes. All CAMTAs share a similar domain organization, with a novel type of sequence-specific DNA-binding domain (designated CG-1). This domain could bind DNA directly and activate transcription, or interact with other transcription factors, not through DNA binding, thus acting as a co-activator of transcription. Investigations of CAMTAs in various organisms imply a broad range of functions from sensory mechanisms to embryo development and growth control, highlighted by the apparent involvement of mammalian CAMTA2 in cardiac growth, and of CAMTA1 in tumor suppression and memory performance.
最近，在各种真核生物中报道了一个新的钙调蛋白结合转录激活因子（CAMTA）家族。所有CAMTA都具有相似的结构域组织，带有一种新型的序列特异性DNA结合结构域（命名为CG-1）。该结构域可直接结合DNA并激活转录，或不通过DNA结合与其他转录因子相互作用，从而作为转录的共激活因子发挥作用。对各种生物体中CAMTA的研究表明，其功能广泛，从感觉机制到胚胎发育和生长控制，其中哺乳动物CAMTA2明显参与心脏生长，CAMTA1参与肿瘤抑制和记忆表现，这突出了其功能的多样性。
