Currier Barbara H, Currier John H, Mayor Michael B, Lyford Kimberly A, Van Citters Douglas W, Collier John P
Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA.
J Arthroplasty. 2007 Aug;22(5):721-31. doi: 10.1016/j.arth.2006.07.006. Epub 2007 Mar 28.
gamma-Barrier packaging is shown to be effective in preventing oxidation of polyethylene during shelf storage and in addressing the problem of early fatigue failure seen in gamma-air-sterilized bearings with long shelf-storage before implantation. The series of gamma-barrier retrievals studied suggests that oxidation occurs in the body via the same mechanism as seen in gamma-air-sterilized bearings. A critical oxidation level is identified above which polyethylene bearings are susceptible to fatigue damage after sufficient cycles of use. Although critical oxidation was not reached in the majority of the retrieved gamma-barrier bearings studied, in vivo oxidation appears to follow an exponential increase with time. The result of in vivo oxidation is expected to be loss of mechanical properties, and susceptibility of polyethylene bearings to eventual fatigue failure.
γ-阻隔包装已被证明在防止聚乙烯在货架储存期间氧化以及解决植入前长时间货架储存的γ-空气灭菌轴承中出现的早期疲劳失效问题方面是有效的。所研究的一系列γ-阻隔回收表明，体内氧化通过与γ-空气灭菌轴承中相同的机制发生。确定了一个临界氧化水平，超过该水平后，聚乙烯轴承在足够的使用周期后易受疲劳损伤。尽管在所研究的大多数回收的γ-阻隔轴承中未达到临界氧化水平，但体内氧化似乎随时间呈指数增加。体内氧化的结果预计是机械性能的丧失以及聚乙烯轴承最终易发生疲劳失效。
