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在全膝关节置换（TKR）设计中，对原始和交联超高分子量聚乙烯（UHMWPE）进行长达6周的人工老化后的化学、机械和摩擦学效应评估 。

Chemical, Mechanical and Tribological Effects of Artificially Aging up to 6 Weeks on Virgin and Crosslinked UHMWPE Evaluated for a TKR Design.

作者信息

Schwiesau Jens, Fritz Bernhard, Bracco Pierangiola, Bergmann Georg, Puente Reyna Ana Laura, Schilling Christoph, Grupp Thomas M

机构信息

Research & Development, Aesculap AG, Am Aesculap Platz, 78532 Tuttlingen, Germany.

Department of Orthopaedic and Trauma Surgery, Musculoskeletal University Center Munich (MUM), Campus Grosshadern, LMU Munich, 81377 Munich, Germany.

出版信息

Bioengineering (Basel). 2025 Jul 24;12(8):793. doi: 10.3390/bioengineering12080793.

DOI:10.3390/bioengineering12080793
PMID:40868307
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12383226/
Abstract

Patients undergo total knee arthroplasty (TKA) at younger ages with the expectation that the devices will perform well over two to three decades. During this time, the ultra-high molecular weight polyethylene (UHMWPE) bearing material properties of the implant may change due to aging induced by radiation and oxygen diffusion or other effects. Vitamin E or other antioxidants are promoted since several years to improve the oxidation resistance of UHMWPE. To compare the effectivity of these substances against established materials, a six weeks aging process was used and the chemical, mechanical and bio-tribological properties were analysed. Highly crosslinked and two weeks aged UHMWPE served as a reference for the currently established aging standards and virgin UHMWPE was aged for six weeks to separate the effects of crosslinking and vitamin E blending. Six weeks artificially aging changed the chemical, mechanical and bio-tribological properties of cross-linked UHMWPE significantly compared to only two weeks artificially aging, leading to cracks and delamination during the highly demanding activities wear test. The degradative effect of extended aging was also observed for virgin UHMWPE. These observations are in good accordance to retrieval findings. Minor changes on the chemical properties were observed for the cross-linked UHWMPE blended with vitamin E without impact on the mechanical and bio-tribological properties.

摘要

患者在较年轻时接受全膝关节置换术（TKA），期望植入装置能在二三十年里良好运行。在此期间，植入物的超高分子量聚乙烯（UHMWPE）轴承材料特性可能因辐射、氧扩散或其他效应导致的老化而发生变化。数年来，维生素E或其他抗氧化剂被推广用于提高UHMWPE的抗氧化性。为比较这些物质与现有材料相比的有效性，采用了六周的老化过程，并对化学、机械和生物摩擦学特性进行了分析。高度交联且经过两周老化的UHMWPE用作当前既定老化标准的参照，将未使用过的UHMWPE老化六周以区分交联和维生素E混合的影响。与仅经过两周人工老化相比，六周人工老化显著改变了交联UHMWPE的化学、机械和生物摩擦学特性，在高要求的活动磨损测试中导致裂纹和分层。对于未使用过的UHMWPE，也观察到了延长老化的降解效应。这些观察结果与翻修研究结果高度一致。对于与维生素E混合的交联UHWMPE，观察到其化学性质有微小变化，但对机械和生物摩擦学特性没有影响。

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本文引用的文献

1
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Arthroplast Today. 2024 Oct 30;30:101550. doi: 10.1016/j.artd.2024.101550. eCollection 2024 Dec.
2
Linear and Volumetric Polyethylene Wear Patterns after Primary Cruciate-Retaining Total Knee Arthroplasty Failure: An Analysis Using Optical Scanning and Computer-Aided Design Models.初次保留交叉韧带全膝关节置换失败后聚乙烯的线性和体积磨损模式：一项使用光学扫描和计算机辅助设计模型的分析
Materials (Basel). 2024 Oct 13;17(20):5007. doi: 10.3390/ma17205007.
3
Oxidation and Damage Mechanisms of Second-Generation Highly Cross-Linked Polyethylene Tibial Inserts.
第二代高度交联聚乙烯胫骨插入物的氧化和损伤机制。
J Arthroplasty. 2024 Dec;39(12):3084-3091. doi: 10.1016/j.arth.2024.06.032. Epub 2024 Jun 19.
4
Head, acetabular liner composition, and rate of revision and wear in total hip arthroplasty: a Bayesian network meta-analysis.头、髋臼衬里成分以及全髋关节置换术的翻修率和磨损：贝叶斯网络荟萃分析。
Sci Rep. 2023 Nov 21;13(1):20327. doi: 10.1038/s41598-023-47670-z.
5
A Review of Early In Vivo Performance of Antioxidant Stabilized Polyethylene for Total Knee Arthroplasty.抗氧化稳定聚乙烯在全膝关节置换术中早期体内性能的研究综述。
J Arthroplasty. 2023 Sep;38(9):1885-1891. doi: 10.1016/j.arth.2023.02.044. Epub 2023 Feb 20.
6
Oxidation in Retrieved, Never-Irradiated UHMWPE Bearings: What Can We Learn About in Vivo Oxidation?从未辐照的超高分子量聚乙烯（UHMWPE）关节中取出的磨损颗粒的氧化：我们能从体内氧化中了解到什么？
J Bone Joint Surg Am. 2023 Feb 15;105(4):293-301. doi: 10.2106/JBJS.22.00571. Epub 2022 Nov 30.
7
The impact of free-radical stabilization techniques on in vivo subsurface mechanical properties in highly cross-linked polyethylene acetabular liners.自由基稳定技术对高度交联聚乙烯髋臼衬垫中体内亚表面力学性能的影响。
J Orthop Res. 2023 Jul;41(7):1531-1537. doi: 10.1002/jor.25502. Epub 2023 Jan 4.
8
Failure Analysis of Ultra-High Molecular Weight Polyethylene Tibial Insert in Total Knee Arthroplasty.全膝关节置换术中超高分子量聚乙烯胫骨假体的失效分析
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9
New polyethylenes in total hip arthroplasty : a 20- to 22-year follow-up study.全髋关节置换术中的新型聚乙烯：20 至 22 年随访研究。
Bone Joint J. 2022 Sep;104-B(9):1032-1038. doi: 10.1302/0301-620X.104B9.BJJ-2022-0434.R1.
10
Is Highly Cross-Linked Polyethylene Safe for Use in High-Flexion Posterior Stabilized Total Knee Arthroplasty?高度交联聚乙烯用于高屈曲后稳定型全膝关节置换术是否安全？
J Arthroplasty. 2023 Feb;38(2):286-292. doi: 10.1016/j.arth.2022.08.025. Epub 2022 Aug 24.