Shurin Galina V, Yurkovetsky Zoya R, Chatta Gurkamal S, Tourkova Irina L, Shurin Michael R, Lokshin Anna E
Department of Pathology, University of Pittsburgh Medical Center, 3550 Terrace Street, Scaife Hall, Pittsburgh, PA 15261, USA.
Cytokine. 2007 Aug;39(2):123-9. doi: 10.1016/j.cyto.2007.06.006. Epub 2007 Aug 8.
Dysbalanced production of inflammatory cytokines is involved in immunosenescence in aging. The age-related changes of the levels of circulating inflammatory mediators and their clinical importance have not been investigated until recently. Still, little is known about the influence of aging on circulating levels of many cytokines, chemokines, growth factors, and angiogenic factors. In the present study, we evaluated the effect of aging on 30 different serum biomarkers involved in pro- and anti-inflammatory responses using multianalyte LabMAP Luminex technology. The simultaneous measurement of serological markers has been done in 397 healthy subjects between 40 and 80 years old. We demonstrated an increase in serum interferon-gamma-inducible chemokines (MIG and IP-10), eotaxin, chemoattractant for eosinophils, and soluble TNFR-II with advancing age. Serum levels of EGFR and EGF, important regulators of cell growth and differentiation, were decreased with age in healthy donors. These data suggest novel pathways, which may be involved in age-associated immunosenescence.
炎症细胞因子的失衡产生与衰老过程中的免疫衰老有关。循环炎症介质水平的年龄相关变化及其临床重要性直到最近才得到研究。然而，关于衰老对许多细胞因子、趋化因子、生长因子和血管生成因子循环水平的影响仍知之甚少。在本研究中，我们使用多分析物LabMAP Luminex技术评估了衰老对参与促炎和抗炎反应的30种不同血清生物标志物的影响。我们对397名年龄在40至80岁之间的健康受试者进行了血清学标志物的同时检测。我们发现，随着年龄的增长，血清干扰素-γ诱导趋化因子（MIG和IP-10）、嗜酸性粒细胞趋化因子（嗜酸性粒细胞的趋化剂）和可溶性肿瘤坏死因子受体-II水平升高。在健康供体中，细胞生长和分化的重要调节因子表皮生长因子受体（EGFR）和表皮生长因子（EGF）的血清水平随年龄增长而降低。这些数据提示了可能与年龄相关免疫衰老有关的新途径。
