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J Physiol. 2007 Oct 1;584(Pt 1):25-30. doi: 10.1113/jphysiol.2007.139451. Epub 2007 Aug 9.
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本文引用的文献

1
Increased body iron stores are associated with poor outcome after thrombolytic treatment in acute stroke.急性卒中溶栓治疗后,体内铁储备增加与预后不良相关。
Stroke. 2007 Jan;38(1):90-5. doi: 10.1161/01.STR.0000251798.25803.e0. Epub 2006 Nov 30.
2
A responsive MRI contrast agent to monitor functional cell status.一种用于监测功能性细胞状态的响应性磁共振成像造影剂。
Neuroimage. 2006 Sep;32(3):1142-9. doi: 10.1016/j.neuroimage.2006.05.009. Epub 2006 Jul 11.
3
Magnetic resonance imaging of the migration of neuronal precursors generated in the adult rodent brain.成年啮齿动物大脑中生成的神经前体细胞迁移的磁共振成像。
Neuroimage. 2006 Sep;32(3):1150-7. doi: 10.1016/j.neuroimage.2006.04.219. Epub 2006 Jun 30.
4
MR imaging of relapsing multiple sclerosis patients using ultra-small-particle iron oxide and compared with gadolinium.复发型多发性硬化症患者使用超小颗粒氧化铁的磁共振成像,并与钆对比。
AJNR Am J Neuroradiol. 2006 May;27(5):1000-5.
5
Cellular MR imaging.细胞磁共振成像。
Mol Imaging. 2005 Jul-Sep;4(3):143-64. doi: 10.1162/15353500200505145.
6
Improved stem cell MR detectability in animal models by modification of the inhalation gas.通过改变吸入气体提高动物模型中干细胞的磁共振可检测性。
Mol Imaging. 2005 Apr-Jun;4(2):104-9. doi: 10.1162/15353500200504196.
7
MRI detection of macrophage activity after experimental stroke in rats: new indicators for late appearance of vascular degradation?大鼠实验性中风后巨噬细胞活性的MRI检测:血管退化晚期出现的新指标?
Magn Reson Med. 2005 Jul;54(1):59-66. doi: 10.1002/mrm.20532.
8
Ferritin as an endogenous MRI reporter for noninvasive imaging of gene expression in C6 glioma tumors.铁蛋白作为一种内源性磁共振成像报告分子用于C6胶质瘤肿瘤基因表达的无创成像。
Neoplasia. 2005 Feb;7(2):109-17. doi: 10.1593/neo.04436.
9
A new transgene reporter for in vivo magnetic resonance imaging.一种用于体内磁共振成像的新型转基因报告基因。
Nat Med. 2005 Apr;11(4):450-4. doi: 10.1038/nm1208. Epub 2005 Mar 20.
10
Histochemical detection of ultrasmall superparamagnetic iron oxide (USPIO) contrast medium uptake in experimental brain ischemia.实验性脑缺血中超小超顺磁性氧化铁(USPIO)造影剂摄取的组织化学检测
Magn Reson Med. 2004 Aug;52(2):403-6. doi: 10.1002/mrm.20142.

使用磁共振成像进行细胞追踪。

Cell tracking using magnetic resonance imaging.

作者信息

Hoehn Mathias, Wiedermann Dirk, Justicia Carles, Ramos-Cabrer Pedro, Kruttwig Klaus, Farr Tracy, Himmelreich Uwe

机构信息

In-vivo-NMR Laboratory, Max-Planck-Institute for Neurological Research, Gleueler Strasse 50, D-50931 Köln, Germany.

出版信息

J Physiol. 2007 Oct 1;584(Pt 1):25-30. doi: 10.1113/jphysiol.2007.139451. Epub 2007 Aug 9.

DOI:10.1113/jphysiol.2007.139451
PMID:17690140
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2277052/
Abstract

Cell tracking by in vivo magnetic resonance imaging (MRI) requires strategies of labelling the cells with MRI contrast agents. The principal routes to achieve efficient cell labelling for neurological applications are discussed with methodological advantages and caveats. Beyond temporo-spatial localization of labelled cells, the investigation of functional cell status is of great interest to allow studies of functional cell dynamics. The two major approaches to reach this goal, use of responsive contrast agents and generation of transgenic cell lines, are discussed.

摘要

通过体内磁共振成像(MRI)进行细胞追踪需要用MRI造影剂标记细胞的策略。本文讨论了在神经学应用中实现高效细胞标记的主要途径及其方法学上的优点和注意事项。除了标记细胞的时空定位外,研究功能性细胞状态对于研究细胞功能动力学也非常重要。本文还讨论了实现这一目标的两种主要方法,即使用响应性造影剂和生成转基因细胞系。