Waters Emily A, Wickline Samuel A
Dept. of Cardiology, Washington University Medical School, Campus Box 8215, Cortex Building, Suite 101, 4320 Forest Park Ave., Saint Louis, MO, 63108, USA.
Basic Res Cardiol. 2008 Mar;103(2):114-21. doi: 10.1007/s00395-008-0711-6.
Molecular imaging is a rapidly growing field with the potential to revolutionize cardiovascular medicine by shifting diagnostic focus from functional abnormalities which occur late in a disease process to the biochemical events which precipitate the earliest stages of disease. MRI is a modality well suited to this task as it allows a variety of contrast mechanisms for detection of epitopes of interest, as well as high-resolution anatomical localization and functional information. In this review, we discuss the widerange of available molecular MRI contrast agents and their application to diseases such as atherosclerosis, thrombus imaging, and stem cell tracking, along with opportunities for molecularly targeted drug delivery.
分子成像作为一个快速发展的领域，有潜力通过将诊断重点从疾病过程后期出现的功能异常转移到引发疾病最早阶段的生化事件，从而彻底改变心血管医学。磁共振成像（MRI）非常适合这项任务，因为它允许使用多种对比机制来检测感兴趣的表位，以及提供高分辨率的解剖定位和功能信息。在这篇综述中，我们讨论了现有的多种分子MRI造影剂及其在动脉粥样硬化、血栓成像和干细胞追踪等疾病中的应用，以及分子靶向药物递送的机会。
