Nöthlings Ute, Murphy Suzanne P, Wilkens Lynne R, Henderson Brian E, Kolonel Laurence N
Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI.
Am J Epidemiol. 2007 Oct 15;166(8):924-31. doi: 10.1093/aje/kwm172. Epub 2007 Aug 9.
Only a few prospective studies have investigated flavonols as risk factors for cancer, none of which has included pancreatic cancer. The latter is usually fatal, rendering knowledge about prevention particularly important. The authors estimated intakes of three flavonols-quercetin, kaempferol, and myricetin-for 183,518 participants in the Multiethnic Cohort Study and examined associations with incidence of pancreatic cancer. Baseline data were collected in Hawaii and California in 1993-1996. Diet was assessed by using a quantitative food frequency questionnaire. During 8 years of follow-up, 529 cases of exocrine pancreatic cancer occurred. Multivariate Cox regression models were calculated to estimate relative risks. Intake of total flavonols was associated with a reduced pancreatic cancer risk (relative risk for the highest vs. lowest quintile = 0.77, 95% confidence interval: 0.58, 1.03; p trend = 0.046). Of the three individual flavonols, kaempferol was associated with the largest risk reduction (relative risk = 0.78, 95% confidence interval: 0.58, 1.05; p trend = 0.017). Total flavonols, quercetin, kaempferol, and myricetin were all associated with a significant inverse trend among current smokers (relative risks for the highest vs. lowest quartile = 0.41, 0.55, 0.27, 0.55, respectively) but not never or former smokers. This study provides evidence for a preventive effect of flavonols on pancreatic cancer, particularly for current smokers.
仅有少数前瞻性研究调查了黄酮醇作为癌症风险因素的情况，其中没有一项研究纳入胰腺癌。胰腺癌通常是致命的，因此了解其预防方法尤为重要。作者在多民族队列研究中估计了183518名参与者的三种黄酮醇（槲皮素、山奈酚和杨梅素）摄入量，并研究了其与胰腺癌发病率的关联。1993 - 1996年在夏威夷和加利福尼亚收集了基线数据。通过使用定量食物频率问卷评估饮食情况。在8年的随访期间，发生了529例胰腺外分泌腺癌病例。计算多变量Cox回归模型以估计相对风险。总黄酮醇摄入量与胰腺癌风险降低相关（最高五分位数与最低五分位数的相对风险 = 0.77，95%置信区间：0.58，1.03；p趋势 = 0.046）。在三种单独的黄酮醇中，山奈酚与最大程度的风险降低相关（相对风险 = 0.78，95%置信区间：0.58，1.05；p趋势 = 0.017）。总黄酮醇、槲皮素、山奈酚和杨梅素在当前吸烟者中均与显著的负向趋势相关（最高四分位数与最低四分位数的相对风险分别为0.41、0.55、0.27、0.55），但在从不吸烟或曾经吸烟的人群中则不然。这项研究为黄酮醇对胰腺癌具有预防作用提供了证据，特别是对当前吸烟者。
